Jennifer Lake's Blog

June 20, 2021

Germ Sense

May 27, 2021

Born Old

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Can ‘normal’ children be born with ‘old’ diseases? Longevity research which lumps Alzheimers and atherosclerosis together with inflammatory asthma, for example, suggests they can by focusing on the role of NAD-dependent sirtuins: “[Sirtuins] mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis, and asthma.” –p24, Lifespan, by David Sinclair, 2019

I once overheard two new mothers pushing their baby strollers past my house and chatting loudly during their early-morning workout: “But the doctor said he was born with asthma!” said one. “Not only that but, did you know…” said the other, and the conversation trailed off with them as they moved. My mind fixed on the words ‘born with asthma’. This was 10 years ago and I still haven’t found a mainstream citation to support the claim, though admittedly not looking hard for it. Asthma, they say, is caused by viruses, and babies indeed are born with those —  apparently  born with a variety of tobacco-type viruses (tobamovirus) in their guts which increase in the first year of life to as much as 50% of viral content in the gut biome as they near age 2.

Tobamoviruses come from plants, it is assumed. Vectors known today include any number of members from all the Life kingdoms.

Asthma, at face value:

Asthma in Children: Risk Factors, Diagnosis, Management

https://my.clevelandclinic.org/health/diseases/6776-asthma-in-children

Asthma is the leading cause of chronic (long-term) illness in children. It affects more than 7 million children in the United States. For unknown reasons, the rate is steadily increasing. Asthma can begin at any age, but most children who have it have their first symptom by age 5.

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Childhood asthma – Symptoms and causes – Mayo Clinic

https://www.mayoclinic.org/diseases-conditions/childhood-asthma/symptoms-causes/syc-20351507

In childhood asthma, the lungs and airways become easily inflamed when exposed to certain triggers, such as inhaling pollen or catching a cold or other respiratory infection. Childhood asthma can cause bothersome daily symptoms that interfere with play, sports, school and sleep.

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Asthma in Infants | AAFA.org

https://www.aafa.org/asthma-in-infants/

Some preschool children get viral infections often. At least half of children with asthma show some sign of it before the age of 5. Viruses are the most common cause of acute asthma episodes in infants 6 months old or younger. How Is Asthma in Infants and Toddlers Different Than Adult Asthma?

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Viral Infections and Associated Factors That Promote Acute …

https://pubmed.ncbi.nlm.nih.gov/29178673

Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway microbiome. Once asthma is established, acute exacerbations are usually associated with infections with respiratory viruses, such as rhinoviruses (RVs)…

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Rhinoviruses are identical to polioviruses, which in turn are identical to certain plant viruses –read on to citation “Can Plant Viruses Cross the Kingdom Border and Be Pathogenic to Humans.”

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[2009] Bugs and asthma: a different disease?

“The prevalence of asthma has dramatically increased in recent decades. Exacerbations of asthma are a large contributor to asthma-related costs, and are primarily caused by viral and atypical bacterial infections. Rhinoviruses (RVs) are the most common viruses detected after an asthma exacerbation. RVs, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) viral infections early in life can induce wheezing and are associated with the development of asthma later in life. Atypical bacterial infections from Mycoplasma pneumoniae and Chlamydia pneumoniae have also been linked to chronic asthma and potential asthma exacerbations. In this article, we will discuss recent developments in viral infections, specifically RV, RSV, and hMPV, and atypical bacterial infections as causes of asthma…” https://pubmed.ncbi.nlm.nih.gov/19387028/

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Life in the Virosphere

Longevity molecules are being discovered in “Plants experiencing stress”—from Lifespan: “[R]esveratrol is produced in greater quantities by grapes and other plants experiencing stress. We also knew that many other health-promoting molecules, and chemical derivatives of them, are produced in abundance by stressed plants; we get resveratrol from grapes; aspirin from willow bark, metformin from lilacs… Plants have survival circuits too, and we think we might have evolved to sense the chemicals they produce in times of stress as an early-warning system, of sorts, to alert our bodies to hunker down [in ‘protection’ mode] as well. What this means, if it’s true, is that when we search for new drugs [or new microbes] from the natural world we should be searching the stressed-out ones: in stressed plants, in stressed fungi, and even in the stressed microbiome populations in our guts. The theory is also relevant to the foods we eat; plants that are stressed have higher concentrations of xenohormetic molecules…” –p131, ibid.

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Hormesis is a characteristic of many biological processes…[in] response to exposure to increasing amounts of a substance or condition…[and is]  generally a favorable biological response to low exposures to toxins and other stressors. The term hormesis comes from Greek hórmēsis “rapid motion, eagerness”, itself from ancient Greek hormáein “to set in motion, impel, urge on”… https://en.wikipedia.org/wiki/Hormesis

—in other words, accelerating stress.

“This review compiles information on how hormesis in plants can be used to achieve new production levels… [by application of pesticides, such as glyphosate, where]..the plants benefit from a low dose whereas are distressed by a high dose which leads to an irreversible and negative outcomes on the health and functions of plants” https://www.sciencedirect.com/science/article/pii/S0147651320310642

Directing hormetic activity by inducing stress ‘toxins’ with chemicals and radiation particularly,  is a controversial practice, not to mention other “trauma-based hormesis.” Largely from insights on what is posted here, hormetic “stress chemicals” produced in response to change are another addition to the category of ‘virus’ .

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The dominant ‘birth’ virus identified in the Nature article below (Aug.2020) and drawn from a small study in 2016, showed Pepper Mild Mottle Virus (PMMoV) as the most abundant ‘reconstructed’ genome, but the classic ‘type species,’ Tobacco Mosaic Virus (TMV) was also found in these infants, though their parents neither smoked nor handled tobacco. By size and shape, PMMoV and TMV are identical. TMV, in rod form, can be extracted from many hundreds of common food plants. There are also disc, ring, and spherical virions of TMV, but that subject will be explored in the next installment (#4) of Planting Viruses—to some extent, already posted in #3.

[2009]…” Typical tobamovirus-like particles (rigid rods ≈300 nm long) were observed in crude plant extracts. According to literature, at least six tobamoviruses infect peppers: Paprika mild mottle virus (PaMMV); Pepper mild mottle virus (PMMoV); Ribgrass mosaic virus (RMV); Tobacco mild green mosaic virus (TMGMV); Tobacco mosaic virus (TMV); and Tomato mosaic virus (ToMV)” …  https://pubmed.ncbi.nlm.nih.gov/30764375/

New ‘pepper’ tobamoviruses have recently been discovered [2008] and this citation is relevant to my grocery shopping—the packaged peppers on my area’s food shelves are imports from Israel.

[2008] “The biological, serological, and molecular characteristics of a newly isolated L4 resistance-breaking isolate of Pepper mild mottle virus (PMMoV) were studied. The new pathotype of PMMoV is closely related to the Israeli pathotypes P1,2 and P1,2,3 of the virus; however, the mosaic symptoms caused by this new pathotype on pepper plants with an L4 genotype were more severe than the mild mosaic symptoms caused by other common pathotypes…”  https://www.apsnet.org/publications/plantdisease/2008/July/Pages/92_7_1033.aspx

[2010] Pepper Mild Mottle Virus, a Plant Virus Associated with Specific Immune Responses, Fever, Abdominal Pains, and Pruritus in Humans

“Recently, metagenomic studies have identified viable Pepper mild mottle virus (PMMoV), a plant virus, in the stool of healthy subjects. However, its source and role as pathogen have not been determined…” https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010041

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[2015]

Can Plant Viruses Cross the Kingdom Border and Be Pathogenic to Humans?

…” Accordingly, plant viruses are not considered to present potential pathogenicity to humans and other vertebrates. Notwithstanding these beliefs, there are many examples where phytoviruses circulate and propagate in insect vectors. Several issues are raised here that question if plant viruses might further cross the kingdom barrier to cause diseases in humans. Indeed, there is close relatedness between some plant and animal viruses, and almost identical gene repertoires. Moreover, plant viruses can be detected in non-human mammals and humans samples, and there are evidence of immune responses to plant viruses in invertebrates, non-human vertebrates and humans, and of the entry of plant viruses or their genomes into non-human mammal cells and bodies after experimental exposure. Overall, the question raised here is unresolved…It is currently considered that phytoviruses only infect plants and therefore, plant viruses cannot cause disease in humans. In the present review, several issues are raised that challenge this paradigm.…”We describe here that some plant and animal viruses are closely related; humans are considerably exposed to plant viruses; plant viruses can enter mammalian cells and bodies and be naturally present in mammals, including humans; and this presence may be non-neutral; plant viruses may trigger events in mammalian cells and elicit immune responses in invertebrates, non-human vertebrates and humans, and was recently associated with clinical symptoms.

…”The distribution of plant and animal viruses within the currently defined taxons indicates that some plant and animal viruses belong to same viral families (Table 1)…  This is true for family Reoviridae, which includes rotavirus, a major cause of gastroenteritis in humans [36], family Rhabdoviridae, which notably includes rabies virus [37], and family Bunyaviridae, which encompasses human pathogens such as Hantaan virus and Toscana virus [38,39,40]. Within the family Rhabdoviridae, genomic organization indicates that some plant viruses of genera Nucleorhabdovirus and Cytorhabdovirus differ from animal viruses of genera VesiculovirusLyssavirusNovirhabdovirus and Ephemerovirus only by the presence of an additional gene coding for a movement protein, a protein essential for the systemic spread of the virus in the host plant [17,18,37,41]….

…”In addition, Cowpea mosaic virus (CPMV), which is a member of family Secoviridae, shares structural features and genetic organization with animal picornaviruses such as polioviruses, coxsackie viruses and Theiler’s murine encephalomyelitis virus (TMEV), which supports the hypothesis that these plant and animal viruses might derive from a common ancestor [43,44]. In addition, pararetroviruses include plant viruses from the family Caulimoviridae, which consists of the only plant viruses with a double-stranded (ds) DNA genome, as well as animal viruses that belong to the family Hepadnaviridae, which includes hepatitis B virus [45]. Similarly, hepatitis E virus, a leading cause of acute hepatitis in humans, was grouped with Beet necrotic yellow vein virus, a plant virus that belongs to the genus Benyvirus, based on phylogeny of RNA polymerases [46]. Recently, endogenous viral elements (EVEs) from plant RNA viruses were detected in 14 insect genomes [47]. Interestingly, EVE sequences very close to those of phytoviruses of the family Virgaviridae were detected in the genome of a mosquito, Aedes aegypti; a fly, Drosophila rhopaloa; and a bee, Bombyx terrestris. The EVE detected in Aedes aegypti was similar to the tobamovirus genome, which is very surprising as no insect vector is known for tobamoviruses…”

https://www.mdpi.com/1999-4915/7/4/2074/htm

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NATURE magazine, August 2020

 “In this work, we report that plant viruses can also be found frequently in the gut and oropharynx of children during their first year of life, even when they are exclusively breast-fed…

“In 100% of the fecal samples and 65% of the oropharynx samples at least one plant virus was identified. Tobamoviruses in the Virgaviridae family were by far the most frequently detected, with tropical soda apple mosaic virus, pepper mild mottle virus, and opuntia tobamovirus 2 being the most common species. Seventeen complete virus genomes could be assembled, and phylogenetic analyses showed a large diversity of virus strains circulating in the population. These results suggest that children are continuously exposed to an extensive and highly diverse collection of tobamoviruses…

“Metagenomic studies describing the composition of eukaryotic viruses in the gastrointestinal and respiratory tracts of children are limited, and only a few of them have included children under 1 year of age5,6,7,8,9,10,11. In addition, most of the reported studies have characterized the virome in diseased children8,9,10,11 and just a few have studied community-based healthy children5,6,7. Therefore, we aimed to determine the diversity and dynamic of the oropharyngeal and gastrointestinal eukaryotic viromes in [healthy] children under 1 year of age in a semi-rural population in Mexico, using next generation sequencing. In addition to human viruses, we found that plant viruses were commonly present in the gut and the oropharynx of children during their first year of life and, surprisingly, they were found as early as 2-weeks after birth in exclusively breast-fed infants. Tobamoviruses, in the Virgaviridae family, were the most abundant, and were present in most of the samples analyzed. Of interest, antibodies to plant viruses have been found in animals, including humans3, and it has also been shown that cowpea mosaic virus can disseminate systemically when orally administered to mice12. Whether the common presence of these viruses at an early age has an effect in the infant’s immune system and maturation of the gut remains to be investigated…

…”Some studies have detected the presence of Virgaviridae sequences in fecal samples of children with particular pathologies. Thus, in a study carried out in the Hunan province of China, 238 fecal samples were collected from pediatric patients (0–12.4 years of age) who were clinically diagnosed with mild or severe hand-foot-and-mouth disease10. In pools of samples from severe cases, 94% of the total viral reads were classified in the family Virgaviridae…

“It is now clear that the bacterial communities in the gastrointestinal tract play a critical role on different human developmental pathways early in life22. In this regard, it is of great interest the considerable exposure that infants can have to plant viruses during the first year of life, as shown by the high frequency of detection of tobamoviruses in both the oropharynx (65%) and fecal (100%) samples starting at least 2 weeks after birth. This raises the question of whether these viruses could have an impact in the maturation of the infant’s immune system or in their healthy development, directly or through interactions with other components of the microbiota, as has been observed for norovirus [Norwalk virus] in a mouse model23. This possibility needs to be investigated.”

(snip) https://www.nature.com/articles/s41598-020-70684-w

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This Nature study excerpted above, like all others purporting to study humans, makes Zero mention of the vaccination status of study subjects. Given its recent date though, it can and should be assumed that participants were vaccinated according to WHO/CDC recommendations. At the moment, Mexico exempts children under 18 from COVID vaccines unlike the U.S. which is now recommending CoVax for 6-month-old babies and pregnant women.

Routine shots for babies at birth in Mexico, now for longstanding, includes BCG (tuberculosis) and HepB. At 2-months they get Rotarix (rotavirus), anti-pneumococcal, and a whopping ‘pentavalent’ vaccine against H.influenzae, pertussis, diphtheria, tentanus and polio. At six months of age they start regular vaccines for influenza and polio (Sabin OPV and Salk IPV). At 12-months adding HepA, varicella (chicken pox) and Triple SRP (measles, mumps, rubella) –and after that, boosters as they grow, HPV at age eleven and so on. https://en.wikipedia.org/wiki/Vaccination_in_Mexico

Most of these vaccines would also have been given to the mothers when they were young and since 2012, pregnant mothers receive an additional Tdap. The ‘Nature’ study picks up its pregnant volunteers in the third trimester—after, presumably, getting their Tdap.

·  Pregnancy and Vaccination: Why Maternal Vaccines Are …

http://www.cdc.gov › vaccines › pregnancy

Tdap Vaccine Tdap vaccine is recommended during every pregnancy, between 27 and 36 weeks gestation (preferably earlier in this period). When given during pregnancy, Tdap vaccine boosts antibodies in the mother, which are transferred to her developing baby. Early third trimester administration optimizes neonatal antibody levels.”

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Before I launch my ‘stress chemical’ explanation for the presence of tobamoviruses in newborns, I’d like to share this complex description of the mRNA CoV vaccines from an interview between Joseph Mercola and Stephanie Seneff.  Touching on a lot of points of virus interaction, this interview also has a beautiful illustration of how our bodies integrate RNA, reverse transcribe it to DNA and pass the genetic ‘signals’ (of more RNA and proteins) on to other cells, including sperm and egg cells.

https://articles.mercola.com/sites/articles/archive/2021/05/23/stephanie-seneff-covid-vaccine.aspx

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Minute 29—

Mercola: “You found that there is a lot of [naturally-existing] reverse transcriptase in our [cellular] DNA…and this causes our body to turn RNA back into DNA…

Seneff: “…we actually have plenty of reverse transcriptase in our own cells… and if these LINEs and SINEs are able to [convert] RNA back to DNA and to put that DNA back into the genome… and those [LINEs, “sometimes called ‘junkDNA’”] …surprisingly is 10% of our DNA… they’re really weird—they fold DNA and stick it in backwards and…do crazy stuff [that’s] so fascinating…  And when people have Alzheimers…[for example] they get multiple copies of that amyloid beta protein…[as] extra genome, with variations in those copies [which] they [made] through RNA…  It’s an evolution, and the mechanism from which we evolve, probably… So, we’re taking that RNA, mutating it –because RNA mutates much more easily than DNA does—and then [transcribing] it back into DNA and sticking it back into the genome… This is a known process associated with cancer and all these neurological diseases…

“And when you have [glyphosate, i.e.] with the body so sick [it’s] trying to mutate its way around those problems… It’s a process we use to try and deal with toxic chemicals in [our] environment…

Mercola: “…So,[mutations] can be transferred down genetically…like editing…

Seneff: “yes, and I was blown away to learn about the sperm… There’s a complete story in it that sperm can take… messenger RNA, external RNA and that can be from a virus or a vaccine, taking it in and converting it to DNA and then producing what’s called plasmids. So the sperm does this: whatever mRNA they come up with…,they make [into] plasmids…which is converted to DNA and put into these little pellets –and all the sperm [not just the ‘lucky’ one] in this [fertilizing] environment [around the egg]…are basically handing over to the egg all these plasmids with nuggets of RNA/DNA in them that they [picked up]… The egg takes it up and puts them into all the cells as it grows and… by the time the child is born, it’s got all these plasmids in there with…code to make [vaccine/viral] proteins… And now that child is not going to have any antibodies to that protein –its going to [detect only] human protein. It’s immune system is going to be trained that this is a natural protein and doesn’t need antibodies to it. So if that child gets exposed to [the corresponding] disease it’s immune system won’t react…  and they’ll be able to carry that virus for their entire lives and pass it on down to their children…

…”Now, there is [a] disease that cows were getting—a diarrheal infection that was a problem—and what would happen is a baby calf would be born with that virus protein belonging to that genome and the calf would carry that virus and spread it to all the cows, so [farmers] became aware that [they] had all these ‘killer’ calves being born and the adult cows were getting sick with the infection that the calves were carrying… So, I think, this can be done with [humans]…

Mercola: …”basically [creating] superspreaders…”

Seneff: “Yes, and they killed these calves…when they found them…because they couldn’t afford to infect an entire herd…with this virus…  So, a virus goes through this process; at first it’s new to the population and causes…disease and …eventually there’s, I think, something in a virus that’s needed , potentially, to get into [the body] system to help cope [with toxins]. 

–end transcript at min.37

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You Are What You EAT –and what eats you!

In light of the ‘healthy’ TMV-like content of baby guts, scrupulous consideration should be given to the current manipulation of tobamoviruses in plants and the discovery of vectoring these “plant” viruses by mosquitos!

Firstly, there’s the “flying syringe” funded in 2010:

·  ‘Flying Syringe’ Mosquitoes Get Bill Gates Funding

http://www.bibliotecapleyades.net/ciencia/ciencia…

“The Bill and Melinda Gates Foundation awarded 100,000 dollars each on Wednesday to scientists in 22 countries including funding for a Japanese proposal to turn mosquitoes into “flying syringes” delivering vaccines. The charitable foundation created by the founder of software giant Microsoft said in a statement that the grants were designed to, “explore bold and largely unproven ways to improve global health.”

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—And then consider decades of experimentation on GMO food and crops with a newer link below to “foreign protein expression” obtained in tobacco: This citation appears to spin out of the same academic network as ’flying syringes’:

[Title] “Improvement of the transient expression system for production of recombinant protein in plants”… [text]”Transgenic plants are generally used to obtain recombinant proteins or identify the localization of proteins…The replication system of plant viruses results in high-level expression of foreign proteins within a few days..[and] can be easily amplified…[such as the] tobamovirus (TMV)-based deconstructed viral system [called] magnIcon [which] has been extensively engineered to achieve high levels of recombinant protein…[demonstrated by the vaccine] ZMapp for Ebolavirus infections…used during a recent outbreak… [Africa, 2014]” https://www.nature.com/articles/s41598-018-23024-y

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And then there’s evidence of tobacco use 12,000 years ago — do you think– as food?

Oldest Known Evidence of Tobacco Use in North America Found in Ice Age Hunting Camp

…. “the most interesting part of the discovery is that there is no direct evidence that people used tobacco past 3,000 years ago, but this research proved its use more than 12,000 years ago.”

https://www.ancient-origins.net/news-history-archaeology/oldest-known-evidence-tobacco-use-north-america-found-ice-age-hunting-camp-020922

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“You are what you eat: Sequence analysis reveals how plant microRNAs may regulate the human genome”

March 2019

Abstract

“Background: Nutrigenomic has revolutionized our understanding of nutrition. As plants make up a noticeable part of our diet, in the present study we chose microRNAs of edible plants and investigated if they can perfectly match human genes, indicating potential regulatory functionalities… Results: Four common plant miRNAs were identified to match perfectly with 22 human transcripts. The identified target genes were involved in a broad range of body functions, from muscle contraction to tumor suppression. We could also indicate some connections between these findings and folk herbology and botanical medicine…”

https://pubmed.ncbi.nlm.nih.gov/30708219/

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“Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi”

March 2017

Background: Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression…  Results: In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples… Conclusions: Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system.”  https://pubmed.ncbi.nlm.nih.gov/28361700/

 

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The Long and Short of RNA

On the frontier of biological complexity is an ‘RNA world’ that prior to the 1980s, research scientists knew little about. They have since learned that most of the genetic material we carry is non-coding, meaning there are no specific proteins associated with it. This is our extraordinary and dynamic epigenome that directs cell functions, behavior, and identity.  Professor John Mattick says in his presentation, The New World of RNA Biology, that “most of the genes in humans do not code for proteins”. He compares the known human “coding regions” with those of nematodes (hookworms, for example )as being numerically equivalent, “which means that [we have] more regulatory genes than genes –which is impossible [it was thought]…so, there’s another conversation about how eukaryotes solve this problem which is through microRNAs…and modularity.”  Here’s his wonderful [one hour] ‘classroom’ video  https://www.youtube.com/watch?v=WdltOXdwo4g

https://en.wikipedia.org/wiki/John_Mattick

RNA interference –RNAi

“RNAi encompasses an array of ancient and sophisticated cellular mechanisms that regulate a variety of biological functions. Argonaute proteins bind many naturally occurring small RNAs to defend against transposable elements, maintain chromosome structure and stability, and regulate developmental timing and differentiation. For example, microRNAs [miRNA] represent a natural form of developmentally-important siRNAs [small interfering RNA]…  [O]ne microRNA [can] regulate hundreds of genes. Humans make more than 500 distinct microRNAs, and the inappropriate production of specific microRNAs has been linked to several diseases…” https://www.umassmed.edu/rti/biology/how-rnai-works/

RNAi, 10 minute video explanation by Maria Portela https://www.youtube.com/watch?v=C-pTiFkg1aU

A basic understanding of ‘RNA world’ is enough to follow the logic of what I’ll call “virus world,” as the lexicon of viruses has indeed absorbed the ‘transcript’ fragments from noncoding RNA (i.e. retrotransposons=endogenous viruses=’jumping genes’, etc.) and the endless variety of enzymes and proteins that are made for our adapting and evolving survival.

According to Dr. Mattick, the structural RNAs which build and shape our genes are those most familiar and studied by science: “There are studies going back to the 1960s showing that there are very stable chromatin-associated RNAs… RNA is the third component of chromatin and it’s nuclease resistant”, so it remains stable, resistant to enzymatic degradation—and those are qualities that make Tobacco Mosaic Virus so very interesting. TMV, in fact, looks like a chromatin stack. More than that, it has an observable relationship with the presence of human beings all over the world and deep into antiquity. TMV has more ‘mysteries’ than just its own genetics to reveal.

chromatin coiled-coil structure

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Ebola, if you’re wondering, looks like TMV. I’ll have more to say (and show) about it in a future ‘Planting Viruses’.  A particular TMV mystery is the “coat protein” homologue amino sequence that matches the human/mitochondria enzyme ‘TOMM40L’ found on chromosome 1.  (ref. https://pubmed.ncbi.nlm.nih.gov/23573274/) The human/plant construct TOMM40L is known as a “translocase”:

“Translocase is a general term for a protein that assists in moving another molecule, usually across a cell membrane. These enzymes catalyze the movement of ions or molecules across membranes or their separation within membranes… It is also a historical term for the protein now called elongation factor G, due to its function in moving the transfer RNA (tRNA) and messenger RNA (mRNA) through the ribosome… Several of these [translocases] involve the hydrolysis of ATP and had been previously classified as ATPases (EC 3.6.3.-), although the hydrolytic reaction is not their primary function…

[Translocase Example #3 (of 3, at the bottom of the page): “Translocase of outer mitochondrial membrane 40 (TOMM40), a protein encoded by the TOMM40 gene, [is an enzyme] whose alleles differentially impact the risk for Alzheimer’s diseasehttps://en.wikipedia.org/wiki/Translocase Alzheimer ‘genes’ also encode on Chromosome 1.

And this is just one example, due probably to the extra attention of medical science on Alzheimers. In 2008 I read a special edition feature in the Los Angeles Times reporting that Americans then in early middle age could expect a 100% rate of Alzheimers.

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Chromosome 1 is the designation for the largest human chromosome… It was the last completed chromosome, sequenced two decades after the beginning of the Human Genome Project… There are 890 known diseases related to this chromosome” –including porphyria and the single-point mutation disease of rapid premature aging called Hutchinson-Gilford Progeria. https://en.wikipedia.org/wiki/Chromosome_1

So far, however, there is only one claim of a completely sequenced chromosome, and it’s not chromosome 1. This past April it was widely published that chromosome 8 is the first –the additional entity sought by the COVID PCR tests.

  Complete Chromosome 8 Sequence Reveals New Genes and Disease …

https://phys.org/news/2021-04-chromosome-sequence-reveals-genes-disease.html

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Look again at chromatin structure as it’s bound into a chromosome. Structure, of itself, is the manifestation of a chemical ‘story’.

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Building with RNA

Architectural RNA in chromatin organization – “RNA plays a well-established architectural role in the formation of membraneless interchromatin nuclear bodies. However, a less well-known role of RNA is in organizing chromatin, whereby specific RNAs have been found to recruit chromatin modifier proteins… Studies… suggest that RNA plays a major direct architectural role in chromatin organization…” https://pubmed.ncbi.nlm.nih.gov/32897323/

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“Mammalian transcriptome analyses elucidated the presence of thousands of unannotated long noncoding RNAs (lncRNAs) with distinct transcriptional units. Molecular characterization and functional classification of these lncRNAs are important challenges in the next decade. A subset of these lncRNAs is the core of nuclear bodies, which are the sites of the biogenesis, maturation, storage, and sequestration of specific RNAs, proteins, and ribonucleoprotein complexes. Here, we define a class of lncRNAs termed architectural RNAs (arcRNAs) that function as the essential scaffold or platform of nuclear bodies. Presently, five lncRNAs from mammals, insects, and yeast are classified as arcRNAs. These arcRNAs are temporarily upregulated upon specific cellular stresses, in developmental stages, or in various disease conditions, and sequestrate specific regulatory proteins, thereby changing gene expression patterns.” https://pubmed.ncbi.nlm.nih.gov/26021608/

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“It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures…” https://link.springer.com/article/10.1007/s13258-020-00929-5

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Some months ago I posted this “shape matters” article which is mostly imagery of the mixed forms that occur in the “contagious virus” illnesses we’re familiar with –flu, for example–  showing rods and spheres next to each other, touching each other, intermingled with the beads-on-a-string assembly that looks like chromatin subunits. I couldn’t say if any of these are “favorable or unfavorable chromatin structures” or even “viruses” as we’re told, but I go forward anyway on the premise of stress chemicals, unhindered by dogmatic contagion theories of disease. You’ll find an Ebolavirus comparison to Tobacco Mosaic Virus there too.

“Virus: Shape Matters” https://jenniferlake.wordpress.com/2020/12/09/virus-shape-matters/

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I’ll repost one ‘influenza’ image for you

H7N9 influenza

And here’s another image not posted in Virus Shape Matters– this is a montage of H1N1

H1N1 influenza

If there’s truth in advertising and these ‘influenza’ pictures are real specimens, what in the world –the RNA World—are we looking at? Image ‘D’ from H1N1, particularly, looks like a typical ‘mosaic’ or ‘mottle’ virus accumulation in plants.

Here’s an image below of infected soybean (glycine max) treated with anti-serum from cowpea mosaic virus –hopefully you can see the similarity in the viral matrix, the ‘stringbean’-like structures. With time and effort I can find a lot of pictures like these for side-by-side comparisons.

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The much-lauded ‘Lifespan’ researcher, David Sinclair writes that “what I’m about to suggest won’t actually come at the cost of human lives… Not even one. But it would require us to confront an idea that many people would find alarming: infecting ourselves with a virus that would quickly move into every cell in our body, turning us into genetically modified organisms. The virus wouldn’t kill; it would do the opposite. Vaccines against senescent cells, [calorie restriction] mimetics, and retrotransposon suppressors are possible pathways to prolonged vitality and work is under way already in labs and clinics around the world…  [A] highly contagious disease…is…nothing more than a faster-acting version of aging.” –p158, Lifespan, David Sinclair, 2019

Immortality science, as we can easily deduce from ‘Lifespan,’ is currently dependent on vaccines. At no available technological point in this longevity treatment theory is there long life without injections. Sinclair sings the praises of vaccination: “the idea of giving a patient a little bit of a disease in order to prevent a lot of disease would have been seen as insane –even potentially homicidal—to many people until Jenner did it in 1796. We now know that vaccines are the single most effective medical intervention in human history in terms of saving and extending lifespans.” –p148, ibid. Edward Jenner’s vaccine subjects inconveniently died of diseases in their early twenties, but HEY! , they lived past their childhoods at a time when so many did not, and that’s life extension. Put that paradigm in your pocket. We now also know that cellular stress has benefits akin to  direct immune challenge. “By engaging our bodies’ survival mechanisms in the absence of real adversity,” writes Sinclair, “will we push our lifespans far beyond what we can today?…The potential permutations are virtually endless.” –p144.   So, we don’t need “real adversity”, like “a little bit of disease” anymore either, right?—just some engagement of our survival mechanisms. “There will come a time in which significantly prolonged vitality is indeed only a few pills away; there are too many promising leads, too many talented researchers, and too much momentum for it to be otherwise.” –p145, Lifespan.

“Life can potentially last forever, as long as it can preserve critical biological information and absorb energy from somewhere in the universe. This doesn’t mean we could be immortal tomorrow…” –p119. “I want to let you in on a secret. I have a window into the future. In 2028, a scientist will discover a new virus, called LINE-1. It will turn out that we are all infected with it. We get it from our parents. It will turn out that the LINE-1 virus is responsible for most other major diseases: diabetes, heart disease, cancer, dementia. It causes a slow, horrible chronic disorder, and all humans will succumb to it, even if they have a low-grade infection. Fortunately, the world pours billions into finding a cure. In 2033, a company will succeed in making a vaccine that prevents LINE-1 infections. New generations who are vaccinated at birth will live fifty years longer than their parents did—it will turn out that that’s our natural lifespan and we had no idea…. [and] it might be truer than you think.” –pp81-82.

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LINE-1 (the LINES and SINES that Stephanie Seneff and Joe Mercola mention) does exist. The LINEs are ‘Long’ and the SINEs are ‘short’ inserts into the very long strands of gene matter, where their function is ‘interference’ but their impulse is ‘repair’:

LINE-1 Retrotransposition Activity in Human Genomes –Jun 25, 2010 · Long Interspersed Element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome…” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013285/

This is no fantasy–“we are all infected with it. We get it from our parents…It causes a slow, horrible chronic disorder and all humans will succumb”  because as David Sinclair points out, “when you disrupt the epigenome by forcing it to deal with DNA breaks, you introduce noise, leading to an erosion of the epigenetic landscape…[creating] bodies turned into chimeras of misguided, malfunctioning cells.” –p60. “Every time there’s a radical adjustment to the epigenome, say after DNA damage from the sun or an X-ray [or an ultrasound, or a vaccine injection], the marbles are jostled…. The marbles are moved… A cell’s identity changes. A skin cell starts behaving differently, turning on genes that were shut off in the womb and were meant to stay  off. Now its 90 percent a skin cell and 10 percent other cell types, all mixed up, with properties [let’s say] of neurons and kidney cells. The cell becomes inept at the things skin cells must do… we say the cell has ex-differentiated…succumbing to epigenetic noise.”—pp59-60

He knows what we know: “the epigenome uses our genome to make the music of our lives.” –p37. “Up close, the epigenome is more complex and wonderful than anything we humans have invented.” –p36.

I accept that disclaimer, and always have. It is no virtue to identify ‘beauty’ in creation and act in variance –deviance– to it. The physicist Edward Teller, ‘father of the H-bomb,’ liked to relate a story of preparing and witnessing a Marshall Island test. He arrived a week before the scheduled explosion which was going to obliterate an entire tropical island and was so genuinely pleased with swimming in the clear lagoon and resting on the beach under the shade palms, as they all did, that he persisted in sharing his delight about the paradise lost. This is the mind of “interference,” defense, and weaponeers. Destruction is the price of knowledge and it is very, very interesting –worth the price because out there, up there, and somewhere in the future is the better world “we” will make.

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“Aging brings us to the precipice. Give any of us 100 years or so, and it brings us all there. In 1825, the British actuary Benjamin Gompertz, a learned member of the Royal Society, tried to explain this upward limit with a ‘Law of Human Mortality,’ essentially a mathematical description of aging. He wrote, “It is possible that death may be the consequence of two generally co-existing causes; the one, chance, without previous disposition to death or deterioration; the other, a deterioration, or an increased inability to withstand destruction.’ …Gompertz could accurately predict deaths due to aging: the number of people alive after 50 drops precipitously, but there is a tail at the end where some ‘lucky’ people remain alive beyond what you’d expect. His equations made his relatives, Sir Moses Montefiore and Nathan Mayer Rothschild, owners of the Alliance Insurance Company, a lot of money. What Gompertz could not have known, but would have appreciated, is that most organisms obey his law…” –p69– “Maintaining proteostasis, preventing deregulation of nutrient sensing, thwarting mitochondrial dysfunction, stopping senescence, rejuvenating stem cells, and decreasing inflammation might all be ways to delay the inevitable. Indeed, I work with students, postdocs, and companies around the globe that are developing solutions to each one of these hallmarks… Anything we can do…we should do…. Together we can build a single dam– at the source. Not just intervene when things go wrong. Not just slow things down. We can eliminate the symptoms of aging altogether.” –p84– “The discovery of the molecules I have described [in Lifespan] can be credited to a lot of serendipity. But imagine what the world will discover now that we’re actively and intentionally looking for molecules that engage our inbuilt defenses. Armies of chemists are now working to create and analyze natural and synthetic molecules that have the potential to be even better at suppressing epignomic noise and resetting our epigenetic landscape. There are hundreds of compounds… and hundreds of thousands more that are waiting to be researched. And it’s very possible that there is an as-yet-undiscovered chemical out there, hiding in a microorganism… And that’s just the natural chemicals, which are typically many times less effective than the synthetic drugs they inspire… It will take some time to sort out which of these molecules is best, when, and for whom. But we’re getting closer every day.” –p145.

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Armies of chemists, and chemists with armies

So, there’s DARPA. How ‘bout them? For years now, maybe decades, they’ve had this Tobacco Mosaic Virus vaccine. In 2012 we were told by DARPA that “this green goo might save your life”. Look up TMV in Wikipedia and you can sample the technologic wonder of what I’d call “nature’s carbon nanotube” and more. It’s particles can unwrap and rewrap into any ‘viral’ shape. This is really my purpose in posting Born Old: babies ‘born with TMV’. Before year 2000, nobody doing mainstream biomedicine research seems to have looked for it inside human beings, but what if it’s always been there and the “stress chemical” prospectors found it? What if it’s part of the ‘junk’ stacked on the tips of our chromosomes, masquerading as noncoding long repeats but really some remarkable human/plant relic that’s kept us alive by supporting creation of the other ‘stress chemicals’ ? What if TMV is the actual origin of the semi-fictitious “LINE-1 virus”  that Sinclair speculates as infecting us all?  Could TMV be the Alpha-Omega “We-Are-As-God—Rule-Of-The-Rod” answer to the immortal question?

I’m asking, I’m looking and I’ll keep you posted when there’s more to come. Army of one.

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Notes, links, and postscripts

Newborn immunity

“The clinical observation that the human newborn infant is uniquely susceptible to certain viral, fungal, protozoan, and bacterial infections has suggested that neonates may have impaired cell-mediated immune function…” https://pediatrics.aappublications.org/content/64/5/822

—cell-mediated immunity, called ‘Th1’ or ‘T1’ immunity, is individually acquired beginning at birth and develops through “training” by challenge. The secondary mechanism is called ‘Th2’ and involves the production of antibodies, normally transferred to infants from their mothers and provided by breastmilk until weaned. Vaccines disruptively over-induce the T2 antibody mechanisms at the cost of T1 cell-system development.

In those first few months, the immune system — especially cell-mediated immunity — becomes more developed. This is very important in helping a child fight off viruses.”…(BUT, here’s the warning, they recommend that “ Keeping your infant up-to-date with vaccines is critical”) https://health.clevelandclinic.org/is-your-newborn-babys-immune-system-strong-enough/ –this is an ‘aligned’ military-medical-pharmaceutical industry entity. 

“… studies of T cell-mediated immunity in human newborns and infants are scarce…” [2005] https://www.researchgate.net/publication/7784936_T_Cell-Mediated_Immune_Responses_in_Human_Newborns_Ready_to_Learn

…and it doesn’t stop them from experimenting with publicly administered vaccines.

2019 testimony statement by Dr. Meryl Nass: “Getting a vaccine approved for use during pregnancy is the newest Pharma gold rush. This despite evidence [16][17] (which CDC disputes) that flu vaccine is associated with a doubling of miscarriage rates, and evidence that anthrax vaccine increases the miscarriage rate.[18] Neither flu nor Tdap vaccines were tested and approved by FDA for use in pregnancy.https://merylnassmd.com/my-testimony-on-legislation-to-remove_4/

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Progeria, the ‘single-point’ mutation disease, is not inherited.

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David A. Sinclair, author of Lifespan, began his rise in research studying Werner’s Disease, which causes rapid aging in early middle age –“average age at death is 46”. Werner’s is associated with chromosome 8.

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Chlamydia, a microorganism associated with chronic asthma, is an NAD-sucking parasite.

https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide

Geoengineering and transbiology research has identified a chlamydia-like entity infecting blood cells https://www.aboutthesky.com/aboutthesky/transbiology

“The assessment is that Chlamydiae or Chlamydiae-like organisms should be considered as a leading candidate for investigation in the Morgellon’s pursuit as well as in the investigation of the aerosol operations.  A more detailed analysis of the rationale behind that assessment will be provided in another paper, Agents of Infection as time and circumstance permit…” https://www.transitieweb.nl/mirror-carnicom-institute/and-now-our-children/index.html

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Jan 2021 – Abstract “The gut microbiome plays an important role in early life, protecting newborns from enteric pathogens, promoting immune system development and providing key functions to the infant host. Currently, there are limited data to broadly assess the status of the US healthy infant gut microbiome. To address this gap, we performed a multi-state metagenomic survey and found high levels of bacteria associated with enteric inflammation (e.g. Escherichia, Klebsiella), antibiotic resistance genes, and signatures of dysbiosis, independent of location, age, and diet. Bifidobacterium were less abundant than generally expected and the species identified, including B. breve, B. longum and B. bifidum, had limited genetic capacity to metabolize human milk oligosaccharides (HMOs), while B. infantis strains with a complete capacity for HMOs utilization were found to be exceptionally rare. Considering microbiome composition and functional capacity, this survey revealed a previously unappreciated dysbiosis that is widespread in the contemporary US infant gut microbiome.” https://www.nature.com/articles/s41598-020-80583-9

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[excerpt, 2015]

The Gut Microbiome’s Role in Asthma

The search for answers in the medical mystery around the recent increase in asthma prevalence, especially for children up to age four, has led researchers to consider changes in the gut and airway microbiome as a contributing environmental factor in the development of this treatable, but uncomfortable, condition.

Susan Lynch and Kei E. Fujimura of the University of California San Francisco present the latest research in mice exploring this relationship, especially how specific types of bacteria alter the presence of different immune cells. Though still an emerging body of work, they believe it is evidence that manipulation of the airway/gut microbiome at an early age could lead to new strategies to prevent or manage asthma.” https://www.sciencedaily.com/releases/2015/05/150513125126.htm

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May 16, 2021

Severe Aging Response Syndrome

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SARS, as in SARS-CoV2, and the invented vaccines inducing it should stand for Severe Aging Response Syndrome, in that all sequelae appear to relate to a rapid depletion of a most necessary nutrient: NAD+, a metabolic ‘redox’ driver that makes 500 or more essential enzymes. In the previous post ‘Grab Your NADS,’ I quote the ‘longevity’ researcher David A. Sinclair as saying “Without any NAD we’d be dead in thirty seconds.”

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An example of vaccine-induced ”aging meltdown” in a young person:

“Whatsherface” posts the morbid adverse reaction of a 12-year-old to Morderna’s mRNA –caught by Max Igan at the Crowhouse, April 29  https://www.bitchute.com/video/JsCu2uAFcQiP/

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Covid, which I’m not suggesting is a virus disease, is an accelerator, like your gas pedal, driving the speed of your vehicle from 10mph (or your current age in mph)to over 100 and getting stuck there! –‘Gone in Thirty Seconds’, huh?!

The biological havoc causes  the regulators called sirtuins (which are ‘silent information regulators’) to rally to the damage areas, which is normally a different and temporary ‘repair’ job for sirtuins, which are designed to go back and ‘silence’ the genes they came from—if they ever make it back.

Cutting to the chase, I’ll re-post a three paragraph quote from Sinclair where he comments on the epigenomic, or gene expression, ‘information theory” of aging:

   “If the information theory is correct –that aging is caused by overworked epigenetic signalers responding to cellular insult and damage—it doesn’t so much matter where the damage occurs. What matters is that it is being damaged and that sirtuins are rushing all over the place to address that damage, leaving their typical responsibilities and sometimes returning [after repairs] to other places along the genome where they are silencing genes that aren’t supposed to be silenced…

   “It’s not hard to intentionally break DNA [to prove it]… You can do it with chemotherapy. You can do it with X-rays. (p48).” 

 [They can do it with vaccines!]

…”[In mice] we’d simply broken the mice’s DNA…and forced the cell to paste, or ‘ligate,’ them back together… Those breaks had induced a sirtuin response…[and] their absence from their normal duties and presence on other parts of the genome altered the ways in which lots of genes were being expressed at the wrong time… The digital [DNA] code…was the same as it has always been. But the analog [epigenetic] machine built to read that code was able to pick up only bits and pieces of the data. (p50).

…”Here’s the vital takeaway: we could age mice without affecting any of the most commonly assumed causes of aging. We hadn’t made their cells mutate. We hadn’t touched their telomeres. We hadn’t messed with their mitochondria…[or] exhausted their stem cells…[A]ll the symptoms of aging…were being caused…by the epigenetic changes that come as a result of DNA damage signals. We hadn’t given the mice all of those ailments. We had given them aging. And if you can give something, you can take it away.” –p52, Lifespan, by David A. Sinclair, 2019, Thorsons/HarperCollins publisher.

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Here’s a paper from David Sinclair about sirtuins:

“Mammalian sirtuins are NAD+-dependent deacylases with a huge range of roles in transcription regulation, energy metabolism modulation, cell survival, DNA repair, inflammation, and circadian rhythm regulation…” 

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.312498

 I’m skipping all the biochemistry details in this post, but you can find just about every accelerated ailment in covid/vaccine reactions mentioned as sirtuin regulated; blood flow, pressure, immune surveillance, T-and-B cell activity, etc., etc., ETC.

Survival may be dependent on how well you grab your NADs.

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Extra-terrestrial Curiosity

Around 1960 or so, the United States launched its first global spy satellite system and called it ARS for Advanced Reconnaissance System, a name changed soon after to ‘Corona’  –you can call it a (S)atellite Advanced Recon.System/Corona or “SARS-Corona” ‘fyou like and read about it in Atomic Oswald Three. Later on, in 2009, I heard about the satellite-based GEIS program, for Global Emerging Infections Surveillance which I speculate was not a space-based ‘watcher’ but a ‘driver’. These articles are listed in the Blog Index.

The ARS ‘name’ can be reckoned to Acute Respiratory Syndrome, which was the illness that came along in 2003 when they added ‘Severe’.

The significance of  “name-tracking,” I believe, is not just symbolic but may be a unifying thread no matter where-in-time the name comes. The program ‘name’ can appear even decades before the ‘event’ which connects them. For example, the new 5G ‘StarLink’ satellite has a naming forebear applied to GMO corn –the ‘StarLink’ Bt corn that was recalled some 20 years ago. Pretty weird name for corn, dontcha think?

In chronological order of underrated bio-catastrophes, the StarLink fiasco was followed by SARS.

StarLink Corn: What Happened | Center for Consumer Research

ccr.ucdavis.edu › biotechnology › starlink-corn-what

“Jun 28, 2017 · The controversy began when traces of DNA from StarLink corn were found in taco shells and other corn related products. Although there are several varieties of Bt corns in the market, StarLink was illegal in human food. It was only approved for animal feed…”

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On the face of it, StarLink  Bt genes in human food products, some 300 of them, were loudly ‘recalled’ in 2000, but like other transgenes, they persist by expanding their environment and jumping species. According to Wikipedia, StarLink was found in Saudi Arabia in 2013 and surely needs an update. Today, the Bacillus thuringiensis bacteria (Bt) among others that carry it are known to cause sub-chronic lung infection and leaky gut syndrome: “ Bt’s aggressive mechanism harms the digestive system by effectively attacking normal gut cells thereby burning holes in the intestines.” https://dreddymd.com/2017/03/26/what-is-the-bt-toxin/

Bt toxins are a particular burden in foods that kids enjoy: milk, ice cream, cereal, pasta, potatoes and more. Claire Hope Cummings wrote in her 2008 book Uncertain Peril, “Worse, the National Research Council says that ‘the evolution of resistance to Bt crops is inevitable’…In itself, gene flow is not necessarily harmful. What matters is the kind of molecule that’s moving around, where it goes, and how it behaves once it gets there. When transgenes used to modify one plant move into another plant, they can become unstable and behave unpredictably. When natural genes do this, they are governed by biological rules that …developed over millennia to deal with gene flow and to keep species separate… Genetic engineering by definition overcomes these rules…[and] is the very essence of invasiveness, by design.” –pp31-34, Uncertain Peril

UnSIRTain perils, if you like my spelling, are rapid aging and disease, long known to be caused by radiation/RF/EMF. Look at the two agencies that funded SARS research: NIAID (Fauci’s fiefdom) and the National Institute of Aging.

I’m going to unwind some of this “gain-of-function” information about the spike protein mentioned by Dr. Fleming in his interview –so stand by and come back in a few days if you care to. The doctors Fleming mentions, Ralph Baric and Peter Daszak, are in my ‘virus’ wheelhouse with their research ‘interests’ such as Norwalk Virus (Baric’s specialty–“the most common cause of gastroenteritis” with symptoms of vomiting and diarrhea), and Daszak’s West Nile and Foot and Mouth Viruses. These are all poliovirus-like pathogens found in the gut, which instinct tells me have everything to do with enterotoxins like the Bt ‘insecticide’genes, the frequency signals coming off systems like GEIS and StarLink, and the epidemic occurrence of flu (polio).

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Shocker: Why is this substance in the Moderna COVID vaccine?

by Jon Rappoport

May 19, 2021

…” It’s called SM-102… [The] data sheet lists the effects of SM-102. Here is the opening note: ‘For research use only, not for human or veterinary use.’ …Then the safety data sheet lights up with adverse effects/warnings re SM-102. For example: ‘Suspected of causing cancer. Suspected of damaging fertility or the unborn child. Causes damage to the central nervous system, the kidneys, the liver and the respiratory system through prolonged or repeated exposure. Very toxic to aquatic life with long lasting effects.’ “  https://blog.nomorefakenews.com/2021/05/19/shocker-why-is-this-substance-in-the-moderna-covid-vaccine/

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Added May 22:

Now, this SM-102 substance is relevant in any amount placed in the context of this “water memory” video from 2014 showing Dr. Luc Montagnier following through on earlier experiments about the ability of water molecules to carry and transmit DNA signals into the surrounding environment –literally to transmit specific frequencies of unique DNA and other molecules through the fluid substrate. Montagnier was a Nobel Prize winner for ‘discovering’ HIV –and the documentation presented by Dr.Fleming is proof of the claim having HIV inserted into the SARS-CoV-2 spike. HIV/AIDS we all remember, induced wasting and ‘rapid aging’ on the sufferer. Dr. Nancy Banks discussed the ‘oxidative’ and ‘nitrosative’ stress disorder in AIDS patients as a ‘redox’ dysfunction and we witnessed in AIDS a kind of ‘aging meltdown’.

“Water Memory” transmission theory, video featuring Luc Montagnier

 

In this program, Montagnier recreates a 2005 HIV water ‘dilution’ experiment where the very fine-tune signals of HIV are detectable after multiple dilutions in water to the point of no DNA being present in the water samples. A second laboratory, far away in Italy, receives the digital signal ‘file’ of the samples, sent by internet, and exposes fresh water to the signal “music” of HIV in order to reconstitute the genetic structure of the HIV –they succeed to 98% accuracy. “This is a turning point in biology” says an Italian colleague. “Unbelievable” says another. At minute 46, Montagnier recaps with “Everything started with the measure of the electromagnetic signals as we found at the beginning [and] contrary to many other diseases, [there were] two types of signals coming from HIV-infected patients. We know the virus is there but now [2014] we’re conducting research on the bacteria—we’re trying to identify the origin of these [other] signals…as we could possibly get rid of the bacteria more easily than the HIV virus itself. That could be a means of stopping the epidemic [of AIDS]”…  [He] has found a bacteria that he thinks is the co-factor [in ‘red’ cells– blood]… [and if he could cure someone of AIDS, says Montagnier], “I would be in heaven, swimming with angels.”

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Dr. Fleming’s expertise as a cardiologist would be the body’s fluid systems (water, blood, electrolytes, cytosol, secretions, etc) and the NAD-dependent angiotensin hormone that regulates them with the angiotensin-converting enzymes –the ACE(2)—receptor domains in this COVID-infiltration crime. His specialty as an MD is cofactoring the virus and bacteria in our fluids.

“The water [memory] theory…talks about signals” says the Montagnier video narration [min 31] and so does longevity researcher David Sinclair [“DNA damage signals”] and we are are very close to admission of treatment by signals alone. The CIA crossed this bridge around the time of ARS-Corona satellites, finding similitude of frequencies to mind-altering drugs.

I would urge you to read ‘EMF Killing Fields’ on the blog –it’s never been more applicable than now. https://jenniferlake.wordpress.com/2012/06/21/emf-killing-fields/ We have the Corona satellites in place in 1964 when along came a ‘new’ virus– though everyone said it was influenza– which was given the name ‘coronavirus’ by David Tyrrell from the UK head of the “Common Cold” unit out of the University of London. Peter Daszak, zoologist and president of EcoHealth Alliance, hails from the same alma mater and so did the core of ‘crystallographers’ who discovered the structure of viral DNA (from tobacco mosaic virus) in the ’50s (Rosalind Franklin’s group, in Planting Viruses). EcoHealth Alliance, says Dr. Feming, “is NIH and the CIA.”

Biology practice went ‘quantum’ in the early 1960s.

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Adding….5/23

The DNA-busters are all around you, transmitting the signals of damage—the ‘blueprints’ are signals. It explains the cellular mayhem which occurs on contact, like misfolding proteins and  ‘arrested development’ from sirtuin displacement, causing among other problems, senescent [‘old’] cells which stop replicating to avoid passing on mutations. This is cell ‘protection’ mode which Bruce Lipton teaches is the counterbalance to ‘growth’, the two modes that can’t occur at the same time. Chemical and radiation exposures in utero can result in babies born old (or not born at all) and, as David Sinclair might say, with the disease of aging.

Welcome to the Telecosm.

   In this one minute video transcribed here, Dr. Pierre Gilbert was filmed in 1995 making the statement that ,”In biological destruction there are organized tempests on the magnetic fields. What will follow is the contamination of the bloodstreams of mankind, creating intentional infections. And [the] vaccines will make [it] possible to control people. The vaccines will have liquid crystals that will become hosted in the brain cells which will become micro-receivers of electromagnetic fields where waves of very very low frequencies will be sent. And through these low frequency waves people will be unable to think—you’ll be turned into a zombie. Don’t think of this as an hypothesis… this has been done. Think of Ruanda.” https://www.bitchute.com/video/g2UOYbt5D62H/

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The Last Mile

In telecom-speak, ‘the last mile’ is the hard-to-reach but ultimate goal of transmitting signal to every surface and person on the planet. Having entered our public technical phraseology sometime in the 1990s, I suggested on this blog after reading George Gilder’s 2000 book ‘Telecosm,’ that the last mile is you. Now, with COVID upon us, I think I can describe it—the ‘comment’ section will be used to further this exploratory definition. Meanwhile, some intriguing questions arise from possibilities in ‘water memory’, like using the fluid medium to create and manufacture ‘de novo’ genes and proteins by “playing the music” of digital microbes.

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UPDATES to the timeline below should include the 1996 establishment of GEIS, the Global Emerging Infections Surveillance program. More updates will go in the rolling comments.

From EMF Killing Fields:

This snip out of the timeline is beginning to tell a story:

1996

–Mad Cow disease is identified, caused by ‘prions’, farmer/scientist Mark Purdey files suit in the UK; originally called “bovine AIDS”

–Feb., US Congress passes the Telecommunications Act of 1996; prohibits local gov’ts and citizens from siting cell towers based on health and environment concerns http://www.stern.nyu.edu/networks/telco96.html

–May, Alzheimer’s world expert, Dr. Tsunao Saitoh, is murdered in La Jolla, California during broad daylight by ‘men in black’

–May-Oct, largest outbreak of E.coli in history; Japan; 17,877 cases, 12 deaths (peak in July) https://jenniferlake.wordpress.com/2011/06/25/shiga-boom/

WAR in the Congo (initiated as ‘first Congo war’), ongoing… Hostilities estimated to have killed 10 million  http://findarticles.com/p/articles/mi_qa5391/is_200109/ai_n21477105/

–July, The US Dept. of Defense issues the Joint Non Lethal Weapons Directive featuring Active Denial acoustic frequency systems http://www.dtic.mil/whs/directives/corres/pdf/300003p.pdf

–US Food and Drug Administration “revised 50-year-old regulations to allow medical researchers to enroll patients.. without their consent” [see Jay Katz obit]  http://www.nytimes.com/2008/11/20/nyregion/20katz.html

–Aug., U.S. Air Force reveals techniques on “Owning the Weather” http://www.chemtrails911.com/docs/00_2008/Chemtrails%20Timeline%201.htm…………..

And let’s not forget:

“New York City’s Office of Emergency Management (OEM) was created in 1996 by Mayor Rudolph Giuliani to manage the city’s response to catastrophes, including terrorist attacks (see 1996). In the years preceding 9/11, it holds regular interagency training exercises… One exercise, which takes place in May 2001, is based on terrorists attacking New York with bubonic plague (see May 11, 2001)… OEM will be preparing for a bioterrorism exercise the morning of 9/11…  http://thirdring.wordpress.com/ ( a blog about the anthrax attacks)

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Part of that story is told in “Blood Coltan…the precious metal in the heart of every mobile [phone] from the Congo” http://wideeyecinema.com/?p=842

   Another part of the story has roots in the late 60s with the development of genetic recombination and the successful achievements of Paul Berg combining E.coli with the SV40 monkey virus “transgene”. SV40, an ingredient in mass-produced vaccines of the 50s and 60s along with HeLa cells, readily ‘expresses’ its genes under the influence of radiofrequency. The rapidly proliferating, gene-swapping E.coli are the most natural bacteria vector in the mammalian life-cycle.

   In 1974, the Director of the NIH was one of the top “health physicists” in the country, Dr. Robert S. Stone of UCLA. Stone participated in the secret human plutonium injection experiments for the Manhattan Project (Atomic Energy Commission). In the early 70s, as the mobile-phone/cellular rollout was underway, NIH Director Stone penned this official note to a colleague: “…a year ago [1973] our concern was limited to only a few [genetically recombined] agents of importance to man, such as the infectious adenovirus 2-SV40 hybrids. In the past year, the technology for the production of autonomously replicating DNA recombinants has burgeoned, and we will have to be concerned not only with possible pathogens of human beings, but also..agents of agricultural and industrial importance…” http://profiles.nlm.nih.gov/ps/access/CDBBGK.pdf

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April 21, 2021

Grab Your NADs!

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Grab your NADs…and take a deep breath…

NAD+, the oxidized form of nicotinamide adenine dinucleotide mentioned in the previous post as lacking in Covid patients, is a key molecule in cell respiration, known as ‘redox’ reactions in the electron transport chain. It works by grabbing electrons (becoming ‘reduced’) and transferring them to other molecules (becoming ‘oxidized’ again) in a cycle that activates and nourishes the all-important cell signal pathways.

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The NAD ‘group’ of molecules are classed as B vitamins – the ‘energy’ vitamins (B3, nicotinic acid, niacin, etc.)—but the more specific NAD+ could very well be in a class by itself. Regenerative medicine is homing in on NAD+ as an exciting field of study in anti-aging, immune health and cell defense.

NAD+ might make you smarter and may also put the ‘smart’ in nanodevices like biosensors and DNA computers which I don’t yet know as to whether these devices can parasitically rob you of your NAD+. Whatever the case, NAD+ deficiency has serious detrimental downstream effects that I’ve learned are associated with the ‘typical’ (and long) list of radiation exposure diseases.

For the moment, I’ll quote some bioresearch documents on NAD+ and say that this post is going to be accumulative.

Research:

“Numerous studies have indicated that four interacting factors, including oxidative stress, mitochondrial alterations, calcium dyshomeostasis and inflammation, play crucial pathological roles in multiple major neurological diseases, including stroke, Alzheimer’s disease (AD) and Parkinson’s disease (PD). Increasing evidence has also indicated that NAD(+) plays important roles in not only mitochondrial functions and energy metabolism, but also calcium homeostasis and inflammation.”

https://pubmed.ncbi.nlm.nih.gov/22204321/

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“Increasing evidence has indicated critical roles of nicotinamide adenine dinucleotide, oxidized form (NAD+) in various biological functions. NAD+ deficiency has been found in models of a number of diseases such as cerebral ischemia, myocardial ischemia, and diabetes, and in models of aging. Applications of NAD+ or other approaches that can restore NAD+ levels are highly protective in these models of diseases and aging. NAD+ produces its beneficial effects by targeting at multiple pathological pathways, including attenuating mitochondrial alterations, DNA damage, and oxidative stress, by modulating such enzymes as sirtuins, glyceraldehyde-3-phosphate dehydrogenase, and AP endonuclease. These findings have suggested great therapeutic and nutritional potential of NAD+ for diseases and senescence.” https://pubmed.ncbi.nlm.nih.gov/29295624/

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Are nanodevices parasitizng your ‘redox’ energy? Read this–  “Confessions of an Engineered Nanoparticle”

https://pieceofmindful.com/2021/04/23/confessions-of-an-engineered-nanoparticle/

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Video of nanodevice in Pfizer vaccine from TimTruth.com https://odysee.com/@TimTruth:b/Pfizer-vaccine-zoomed:e

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According to David A. Sinclair, PhD, in his 2019 book “Lifespan”,  humans and other lifeforms have two modes of generating the necessary information that sustains life; one being the DNA/RNA ‘digital’ encoding of genomes (genetic) and the other being the heritable ‘analog’ activity of metabolism (epigenetic). He writes that “Unlike digital, analog information degrades over time—falling victim to the conspiring forces of magnetic fields, gravity, cosmic rays, and oxygen. Worse still, information is lost as it’s copied…  [But]…As cloning beautifully proves, our cells retain their youthful digital information even when we are old.”  As Sinclair describes it, “The Information Theory of Aging starts with the primordial survival circuit we inherited from our distant ancestors. Over time, as you might expect, the circuit has evolved… Scientists have found more than two dozen [survival circuits] within our genome. Most of my colleagues call these ‘longevity genes’… But these genes don’t just make life longer, they make it healthier, which is why they can also be thought of as ‘vitality genes.’ Together, these genes form a surveillance network within our bodies, communicating with one another between cells and between organs by releasing proteins and chemicals into the bloodstream, monitoring and responding to what we eat, how much we exercise, and what time of day it is… And now that we know [about] these genes…, scientific discovery has given us an opportunity to explore and exploit them… [u]sing molecules both natural and novel, using technology both simple and complex… we can read them, turn them up and down, and even change them altogether.

   “The longevity genes I work on are called ‘sirtuins,’ named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body…  [S]irtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD…  [The] loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be  a primary reason our bodies develop diseases when we are old but not when we are young.

   “Trading reproduction for repair, the sirtuins order our bodies to ‘buckle down’ in times of stress and protect us against the major diseases of aging: diabetes and heart disease, Alzheimer’s disease and osteoporosis, even cancer. They mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis and asthma. They prevent cell death and boost mitochondria, the power packs of the cell. They go to battle with muscle wasting, osteoporosis, and macular degeneration. In studies on mice, activating the sirtuins can improve DNA repair, boost memory, increase exercise endurance, and help the mice stay thin, regardless of what they eat. These are not wild guesses as to their power; scientists have established all this… And in no small measure, because [NAD+dependent] sirtuins do all of this based on a rather simple program—the wondrous gene B in the survival circuit—they’re turning out to be more amenable to manipulation than many other longevity genes. They are, it would appear…the key to understanding how our genetic material protects itself during times of adversity, allowing life to persist and thrive for billions of years.”  —pp22-25, Lifespan, by David A. Sinclair, 2019

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Quantitative Proteomic Analysis Reveals the Deregulation of Nicotinamide Adenine Dinucleotide Metabolism and CD38 in Inflammatory Bowel Disease

[April 2019]…”In the current study…  proteomic differences between intestinal tissue from health controls, patients with Crohn’s disease (CD), and patients with ulcerative colitis (UC) were compared…  When proteins with fold change >1.2 or <0.84 and P value < 0.05 between groups were considered differentially expressed, the expression of 10 proteins, including CD38, involved in the nicotinamide adenine dinucleotide (NAD) metabolism and signaling pathway showed significant changes in IBD. Using the NCBI GEO database, we confirmed increased CD38 mRNA expression in patients with UC and in mouse colitis models. Protein CD38 expression was higher in CD and UC than in normal controls. CD38 expression was higher in inflamed tissues than in noninflamed tissues, and CD38 was located in F4/80-positive cells. Our study may provide novel insights into the molecular pathogenesis of IBD. Further studies are required on the role of NAD metabolism and CD38 in intestinal inflammation.”  https://pubmed.ncbi.nlm.nih.gov/31179321/

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NAD Metabolites Analysis Service – Creative Proteomics

http://www.creative-proteomics.com › services › nad

“…The pyridine dinucleotide, NAD+, is a substrate of sirtuins and coenzyme for hydride transfer enzymes and other NAD+-dependent ADP ribose transfer enzymes. It is a unique cellular molecule produced from the pyridine mononucleotides nicotinic acid mononucleotide (NaMN) or nicotinamide mononucleotide (NMN)”

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Assays for NAD +-Dependent Reactions and NAD + Metabolites

pubmed.ncbi.nlm.nih.gov › 30097862

“Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential redox cofactor and signaling molecule that controls the activity of enzymes involved in metabolism, DNA repair, and cellular survival, such as the PARPs, CD38, and the sirtuins. Here, we describe three methods for measuring the activity of these enzymes: the etheno-NAD+ assay measures NAD+ hydrolase activity using an NAD+ analog to produce a fluorescent product that is measured in real time; the PNC1 assay converts a native product of NAD+ hydrolysis, nicotinamide, into a quantitative fluorescent readout; and liquid chromatography tandem mass spectrometry (LC-MS/MS) is used to characterize the entire NAD+ metabolome in a sample. These methods will enable new insights into the roles that NAD+ and the enzymes that utilize it play in health and disease.”

https://pubmed.ncbi.nlm.nih.gov/30097862/

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NAD deficiency and Cytokine Storms

Researchers have learned that NAD deficiency corresponds to increased ‘CD38’:

“CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling…  CD38 is most frequently found on plasma B cells, followed by natural killer cells, followed by B cells and T cells, and then followed by a variety of cell types…  [It was] discovered to be not simply a marker of cell types, but an activator of B cells and T cells…[and] can function either as a receptor or as an enzyme. As a receptor, CD38 can attach to CD31 on the surface of T cells, thereby activating those cells to produce a variety of cytokines…  The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas,[28] solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions. CD38 increases airway contractility hyperresponsiveness, is increased in the lungs of asthmatic patients, and amplifies the inflammatory response of airway smooth muscle of those patients. ”  https://en.wikipedia.org/wiki/CD38

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“Without any NAD we’d be dead in thirty seconds”

David Sinclair explains:

“In 2002, antioxidants were all the rage. They might not have been the antiaging and health panaceas some believed them to be, but that wasn’t yet known. One of [those] antioxidants…was resveratrol, a natural molecule that is found in red wine and that many pants produce in times of stress… [Konrad] Howitz and I were fascinated by the fact that resveratrol is produced in greater quantities by grapes…experiencing stress. We aso knew that many other health-promoting molecules, and chemical derivatives of them, are produced in abundance by stressed plants; we get resveratrol from grapes, aspirin from willow bark, metformin form [‘French’] lilacs, epigallocatechin gallate from green tea, quercetin from fruits, and allicin from garlic. This, we believe, is evidence of xenohormesis –the idea that stressed plants produce chemicals for themselves that tell their cells to hunker down and survive… What this means, if it’s true, is that when we search for new drugs from the natural world we should be searching the stressed-out ones; in stressed plants, in stressed fungi, and even in the stressed microbiome populations in our guts. The theory is also relevant to the foods we eat; plants that are stressed have higher concentrations of xenohormetic molecules that may help us… Look for the most highly colored ones because xenohormetic molecules are often yellow, red, orange, or blue. One added benefit: they tend to taste better… –pp130-131, Lifespan

   “As it turned out, resveratrol wasn’t very potent and wasn’t very soluble in the human gut… [But] By studying resveratrol, we also learned that it is possible to activate sirtuins with a chemical. This prompted a flood of research into other sirtuin-activating compounds called STACs that are many times more potent than resveratrol… There are today hundreds of chemicals that have been demonstrated to have an effect on sirtuins…  NAD, sometimes written as NAD+…has an advantage over other STACs because it boosts the activity of all seven [human] sirtuins… And because NAD is used by over five hundred different enzymes, without any NAD, we’d be dead in thirty seconds.” –pp133-134, Lifespan

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The Deep COVID Agenda Emerging….

At this point, the NAD subject is going to diverge. I’ll make a sequel about Boosting Your NADs, but for now, I’m going to pursue the questions already arisen from the ‘nanodevice’ proposition above and the extension of work from prior posts; Making and Faking Viruses and the series-in-progress Planting Viruses From Plants! – all linked here  https://jenniferlake.wordpress.com/2021/02/03/making-and-faking-viruses/

Zombie Apocalypse

Dr. Sinclair advances his explanation of NAD-dependent sirtuins and anti-aging as a measure of how well our bodies eliminate “senescent cells”—old cells that live on past their ‘Hayflick Limit’ or are simply turned off and do not reproduce by division. He writes,

 “Small numbers of senescent cells can cause widespread havoc. Even though they stop dividing, they continue to release tiny proteins called cytokines that cause inflammation and attract immune cells called macrophages that then attack the tissue. Being chronically inflamed is unhealthy: just ask someone with multiple sclerosis, inflammatory bowel disease, or psoriasis. All these diseases are associated with excess cytokine proteins. Inflammation is also a driving force in heart disease, diabetes and dememtia. It is so central to the development of age-related diseases that scientists often refer to the process as ‘inflammaging.’ And cytokines don’t just cause inflammation: they cause other cells to become zombies, like a biological apocalypse. When this happens, they can even stimulate surrounding cells to become a tumor and spread. We already know that destroying senescent cells in mice can give them substantially healthier and significantly longer lives. (–p150) Cellular senescence is a consequence of our inherited primordial survival circuits which evolved to stop cell division and reproduction when DNA breaks were detected…  [and] if DNA breaks happen too frequently or they overwhelm the circuit, human cells will stop dividing, then sit there in a panic trying to repair the damage, messing up their epigenome and secreting cytokines…  Senescent cells, after all, don’t divide which means that cells with mutations aren’t able to spread and form tumors…

“This is where ‘antagonistic pleiotropy’ comes into play: the idea that a survival mechanism that is good for us when we are young is kept…[in spite of] any problems it might cause when we get older…  So we live longer [now] –and evolution hasn’t had a chance to catch up. We’re plagued by senescent cells, which might as well be radioactive waste. If you put a tiny dab of these cells under a young mouse’s skin, it won’t be long before inflammation spreads and the entire mouse is filled with zombie cells that can cause premature signs [and diseases] of aging.” –pp152-153.

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‘Virus drugs’ and ‘stress chemicals’

Sinclair’s ‘Lifespan’ moves on from zombie cells to ‘telomeres,’ the DNA repeats on the ends of chromosomes that shorten and become exposed and ‘frayed’ over damaging time.

He writes,”The selfish genes…called LINE-1 retrotransposons, and their fossil remnants, make up about half of the human genome, what is often referred to as ‘junk DNA.’ It’s a lot of genetic baggage… In young cells, these ancient ‘mobile DNA elements’ also known as retrotransposons are prevented by chromatin from jumping out of the genome, then breaking DNA to reinsert themselves elsewhere. We and others have shown that LINE-1 genes are bundled up and rendered silent by sirtuins. But as mice age, and possibly as we do as well, these sirtuins become scattered all over the genome, having been recruited away to repair DNA breaks elsewhere, and many of them never find their way home. This loss is exacerbated by a drop in NAD levels… Without sirtuin to spool the chromatin and silence the transposon DNA, cells start to transcribe these endogenous viruses. This is bad. And it only gets worse.”—pp154-155

Endogenous viruses? From your own traveling DNA? Indeed. Finally, a flat and straightforward statement from the ‘lab’.  The ‘viruses’ inside you come from your own disintegrating DNA, the “retrotransposons” we call retroviruses, and were called “jumping genes” by their discoverer Barbara McClintock in the 1920s after examining X-irradiated corn plants. In a continuous flow from the paragraph above, David Sinclair writes:

 “Over time, as the mice age, the once silent LINE-1 prisoners [held by telomeres] are turned into RNA and the RNA is turned [transcribed] into DNA which is reinserted into the genome at a different place. Besides creating genome instability and epigenomic noise that causes inflammation, LINE-1 DNA leaks from the nucleus into the cytoplasm where it is recognized as a foreign invader. In response, the cells reease even more immunostimulatory cytokines that cause inflammation throughout the body…  Convincing evidence has come from experiments showing that antiretrovirals, the same kinds used to fight HIV, extend the lifespan of SIRT6 [knockout] mice about twofold. It may turn out that, as NAD levels decline… sirtuins are rendered unable to silence retrotransposon DNA. Perhaps one day, safe antiretroviral drugs or NAD boosters will be used to keep these jumping genes silent… [before] total anarchy ensues…  In 2018, scientists at Stanford University reported that they had developed an inoculation… with stem cells…” –p155

“What if we could reset the aging clock and prevent cells from ever losing their identity and becoming senescent in the first place?… Yes, the solution to aging could be cellular reprogramming, a resetting of the landscape… The DNA blueprint to be young, after all, is always there even when we are old… (–p158). The implications of these experiments are profound. What they show is that aging can be reset.” (–p161) …I  predict, and my students are now showing in the lab, that we can use [genetic]…switches not just to reset our cells in petri dishes but to reset an entire body’s epigenetic landscape…sending sirtuins back to where they came from, for instance. Cells that have lost their identity during aging can be led back to their true selves… We are making progress every week…by delivering reprogramming factors. The pace of discovery is mind spinning.” –164

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Payload- carrying virus –like your ‘virus’—has long been the treatment of choice and also constitutes the ‘future treatment’ of David Sinclair’s anti-aging cure. During the 1990s, the poliovirus was rigorously experimented with as a delivery vehicle, but often resulted in cancer, cells with lost identity – Oops. It turned out that poliovirus existed on the margin of “error catastrophe,” able and likely to mutate out of existence because of its very small genome: That is, unless the poliovirus is continuously injected. One fork-in-the-road for poliovirus research has been to recreate it from lab chemicals and override its potential genomic instability, accomplished by Eckard Wimmer and published in 2003—at just the time of the appearance of a much larger genome virus, SARS, now taking its own forks. And here’s some ‘news’: The poliovirus is identical to several small plant viruses that might typically pass through your gut and was originally obtained for vaccines from human feces. More news: “plant viruses don’t exist as such” –so, are they better termed as “stress chemicals”?

But really it’s all in the packaging and labels:

“Chromatin is a complex of DNA, protein and RNA found in eukaryotic cells.[1] Its primary function is packaging long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division, preventing DNA damage, and regulating gene expression and DNA replication. During mitosis and meiosis, chromatin facilitates proper segregation of the chromosomes” https://en.wikipedia.org/wiki/Chromatin

And, yup, it’s NAD+ dependent.

I was taught in nursing school that a ‘pathogen’ was simply a microbe out of place. What’s a ‘microbe’?– just a bunch of molecules that stick together. Don’t be fooled by jargon.

Chromatin is a precious structural element that provides a ‘slinky’-like coil shape to DNA, allowing it to become a spooled ‘coiled coil’. Wikipedia shows two images of chromatin; the twisted “30 nanometer fiber” of a chromatin segment and the stacked tube formation of chromatin fibers that link together.

Stacked chromatin ‘linkers’ looks like this top row. The bottom row shows cross-section ‘discs’

Shape-wise, and shape matters, a chromatin tube is a match for a familiar plant ‘virus’ called Tobacco Mosaic Virus (TMV) and its extended family of rod-shaped viruses. TMV is the first discovered virus in viral history (which was then only a fluid extract) and among the most investigated—considered the model ‘type species’ of rod-shape crystals infecting many hundreds of common food plants. It is also the principal ‘stress chemical’ subject in the Planting Viruses series.

   In a novel 1957 experiment by Heinz Fraenkel-Conrat at UCBerkeley, TMV was dissolved and reconstituted under a microscope, producing ‘shorter’ rods –very similar, I think, to shorter telomeres which are markers of aging and associated in this work to a deficiency of NAD. Most interesting perhaps is that commercial niacin, our vitamin B3 ‘supplement,’ was historically and may still be derived from tobacco. Tobacco makes NAD and then NAD’s derivative, niacin, is turned back into NAD when we eat it. See? Is the extract niacin as nutritionally good as the original tobacco NAD+ ? Is it better to just eat tobacco? It’s a good question worth pursuit, and so is asking if chromatin and TMV are the same. If so, the ‘structural’ TMV could be the carrier of life-giving NAD and might supply an answer to the hydrogel fiber phenomenon known in this blog as “TMV-PVP.” The experimental combination of the chromatin-like Tobacco Mosaic Virus and the substance called polyvinylpyrrolidone (PVP) coagulates into a “branched hollow fiber” resembling blood vessels that grow. Back in 2012, I found this substance while looking for possible sources of Morgellon’s extrusions. TMV-doped PVP looks identical to some of the Morgellon’s specimens I’ve seen– written up here (see the blog index) as ‘Morgification.’ To my horror, PVP is used extensively as a filler and food additive. The TMV-PVP combo seems to have a life of its own. An NAD-dependent life.

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TMV graphic above as both discs and stacked tube, showing the ‘skirt’ of  proteins that decorate the helical core.

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March 2010 — “Branched hollow fibers are common in nature, but to form artificial fibers with a similar branched hollow structure is still a challenge. We discovered that polyvinylpyrrolidone (PVP) could self-assemble into branched hollow fibers in an aqueous solution after aging the PVP…. Our work suggests that the self-assembly of the PVP molecules in the solution can serve as a general method for directing the formation of branched hollow inorganic fibers. The branched hollow fibers may find potential applications in microfluidics, artificial blood vessel generation, and tissue engineering.” http://europepmc.org/article/PMC/2844465

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*This ‘search clip’ below, offered at face value, is an indicator of nanomaterials from TMV-PVP

Genetically Improved Monolayer-Forming Tobacco Mosaic Viruses …

http://www.academia.edu › 12687712

“Thus, a precursor solution with a ratio of [PVP]/ composite 30%TMV-His6 mutant (30% His6CP/70% wt CP) [Zn2+]/[TEAOH] = 1:1.3:2.8 and final concentrations of [Zn2+] = are known to bind mono- and divalent metal ions.29 These 11.4 mM, [PVP] = 8.6 mM, and [TEAOH] = 24.3 mM were obtained. “

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3 images of the same ‘Morgellons’ extrusion over time on the back of a persons upper arm. Is this an artificial NAD-dependent lifeform? The person who suffers this disorder reports chronic and crushing fatigue. These pictures are presented in the program ‘From Chemtrails to Pseudo-life, Part 2, Living in the Manhattan Project’ by Sofia Smallstorm.

Sofia Smallstorm – Chemtrails to Pseudo Life Part 2

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So, what about ‘viruses’ in general –are they also NAD+dependent ‘lifeforms’ (better termed ‘stress chemicals’) responsible for the crushing fatigue of acute illness like flu and worse?



(Above) ‘rod and sphere’ electron microscope image of H5N1 influenza: We’re unaccustomed to seeing the rod-shape stack tubes of influenza, looking very much like Tobacco Mosaic Virus. Current EM images of viral infections show TMV-like rods all over the place. Most notably,  a small but recent study ‘isolated’ TMV in stool from exclusively breast-fed infants under 4 weeks of age whose parents never handled tobacco but were agricultural workers. Sixteen other “plant viruses” similarly shaped (liked Pepper Mild Mottle Virus, PMMoV) were also found passing the gut of these newborns though they had never tasted anything other than mothers’ milk. Is this proof of conferred maternal immunity or actually proof that the so-called viruses are native particles of the human genome, loaded with NAD energy? Is NAD the ‘power’ of ‘viruses’, for good and ill?

(Above) Electron Micrograph of H7N9 influenza

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Which, what and where’s the flu virus? Are we really looking at viruses?

“In the same way that genetic information is stored as DNA, epigenetic information is stored in a structure called chromatin. DNA in the cell isn’t flailing around disorganized, it is wrapped around tiny balls of protein called histones. These beads on a string self-assemble to form loops, as when you tidy your garden hose…by looping it into a pile… If you could somehow plug one end of the DNA into a power socket and make the histones flash on and off, a few cells could do you for holiday lights…  Epigenetic information is what orchestrates the assembly of a human newborn made up of 26 billion cells from a single fertilized egg and what allows the genetically identical cells in our bodies to assume thousands of different modalities. If the genome were a computer, the epigenome would be the software.” –p21, Lifespan

“A few recent studies have suggested that the so-called selfish genes we all carry in our genome, called LINE-1 elements, replicate and cause cellular havoc as we get older, accelerating our physical demise… Does it matter whether LINE-1 comes from your parents directly or via a virus?   Would you want to eradicate LINE-1 from humanity or let it grow in your kids and inflict horrible diseases on them? Would you say that LINE-1 causes a disease or not?… Whether it’s a virus, a selfish DNA element, or simply the makeup of our cells that causes these health problems, what’s the difference? The end result is the same.” –p82, ibid.

Genes behaving badly seems to be Dr. Sinclair’s point in Lifespan. Despite the Human Genome Project announcement in 2003 that mapping was complete, he writes, “it really wasn’t. There  were, in fact, huge gaps in the sequence… The parts of the genome that were missing, generally overlapping sections of repetitive nucleotides, were just not considered important. These were areas of the code…once derided as ‘junk DNA’ …[and]disregarded as ‘noncoding.’  From… the best minds in science at the time, those regions were little more than ghosts of genomes past, mostly remnants of dead hitchhiking viruses that had integrated into the genome hundreds of thousands of years ago… Yet by some estimates, that genetic dark matter accounts for as much as 69 percent of the total… [Since 2003, scientists have found thousands more genes, with some tiny ones] as short as 21 base pairs…[but] there’s something we still won’t be able to find. We won’t be able to find an aging gene…because our genes did not evolve to cause aging.” –pp27-28, Lifespan

–Read: “did not evolve to cause aging” or disease because in this mindset aging is disease leading to untimely death.

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He states: “If the information theory is correct –that aging is caused by overworked epigenetic signalers responding to cellular insult and damage—it doesn’t so much matter where the damage occurs. What matters is that it is being damaged and that sirtuins are rushing all over the place to address that damage, leaving their typical responsibilities and sometimes returning [after repairs] to other places along the genome where they are silencing genes that aren’t supposed to be silenced… It’s not hard to intentionally break DNA [to prove it]… You can do it with chemotherapy. You can do it with X-rays. (p48).

…”[In mice] we’d simply broken the mice’s DNA…and forced the cell to paste, or ‘ligate,’ them back together… Those breaks had induced a sirtuin response…[and] their absence from their normal duties and presence on other parts of the genome altered the ways in which lots of genes were being expressed at the wrong time… The digital code…was the same as it has always been. But the analog machine built to read that code was able to pick up only bits and pieces of the data. (p50).

…”Here’s the vital takeaway: we could age mice without affecting any of the most commonly assumed causes of aging. We hadn’t made their cells mutate. We hadn’t touched their telomeres. We hadn’t messed with their mitochondria…[or] exhausted their stem cells…[A]ll the symptoms of aging…were being caused…by the epigenetic changes that come as a result of DNA damage signals. We hadn’t given the mice all of those ailments. We had given them aging. And if you can give something, you can take it away.” –p52, Lifespan, by David A. Sinclair, 2019, Thorsons/HarperCollins publisher.

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Wrap-up and Un-wrap-up

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In this 2021 experiment to create ‘self-sufficient’ engineered cells, mutant E.coli use NAD to generate an ‘alternative’ redox circuit that substitutes the nucleobase cytosine (‘C’, and CTP) for adenine (‘A’, ATP), creating an NCD-dependent circuit, versus an NAD-dependent circuit, which the researchers anticipate as useful in synthetic biology. Their successful conclusion suggests,“This will be amenable to those on-going efforts using non-natural bases and non-natural amino acids to expand our capacity interms of understanding and reprograming life.”

They write: ”To facilitate NCD-linked redox chemistry in vivo, it is essential to realize NCD biosynthesis. In bacteria, nicotinic acid mononucleotide (NaMN) adenylyltransferase (NaMNAT) catalyzes the condensation of ATP and NaMN to form nicotinic acid adenine dinucleotide (NaAD) (Fig. 1a), which is the key step for de novo NAD biosynthesis16. Conceptually, if the binding pockets of ATP and NaMN of NaMNAT [its analog enzyme] are redesigned to favor cytidine triphosphate (CTP) and NMN [the common vitamin product of NAD used by humans], respectively (Fig. 1b), the engineered enzyme is expected to make NCD following a similar condensation mechanism, and can be designated as NCD synthetase (NcdS). As both CTP and NMN are endogenous metabolites, no auxiliary nutrients are required to synthesize NCD by those NcdS-empowered cells… However, it is intimidating to engineer a two-substrate enzyme for active variants specific with two new substrates. On one hand, simultaneous mutating key residues within two-substrate-binding pockets will lead to large [metabolite] libraries beyond our screening capacity. On the other hand, engineered molecular interactions favoring one substrate may have unanticipated effects on those for the other, and vice versa.”

…and what happens to the organism?

“Again, NCD production led to reduced NAD levels…”

Read it here, April 2021—Nature Magazine

https://www.nature.com/articles/s41467-021-22357-z

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Be back for more ‘wrap up’….posting in progress…..

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April 17, 2021

Plant Control and Smokin’ Genius

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This post is really a ‘side note’ extension of the Planting Viruses series, which I alternatively call “TMV to CoV” (Tobacco Mosaic Virus to Coronavirus), with the intent of emphasizing effects on human spirituality and intelligence—central, and not ‘side’, issues OF COURSE. Plants by all measure have vastly accelerated our human success on this planet. Knowledge of plant use and knowledge from plants define much of our sacred heritage. The hologenomes mediated through plants possibly represent the greatest bounty of living intelligence in the galaxy –and therefore, significantly representing human control and oppression. Plants are at once animal, mineral and vegetable; extraordinary, powerful and dangerous.

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To wit, here’s a 1999 documentary about the Pacific Islanders of Bougainville maximizing their use of coconuts to fight for self-rule against the incursions of Rio Tinto Zinc, the Australian and Papua New Guinea governments: The Coconut Revolution https://topdocumentaryfilms.com/the-coconut-revolution/

Here are two videos demonstrating our ancient, religious, and sophisticated relationships with plants:

Graham Hancock’s courageous 19 minute TEDx (The War on Consciousness) talk on “Mother Ayahuasca’s” instruction to give up his cannabis habit.  https://www.youtube.com/watch?v=Y0c5nIvJH7w

The Pharmacratic Inquisition, from 2007 (2hrs) https://video.search.yahoo.com/search/video?fr=yfp-t-s&ei=UTF-8&p=pharmacratic+inquisition#id=1&vid=3afd05ee9a4028861c3ee2e71dbb27c0&action=click

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The hologenome concept applied to ‘sacred’ tobacco is relevant to previous and future Planting Viruses posts –perhaps necessary to an exposition of the current uptake and applications of tobacco viruses in nano-bio-engineering. The DREADD technology mentioned by Charles Morgan in ‘Project POSSESSION’  is advancing with the use of tobacco viruses and yeast fungi –plant ‘bionts’. Morgan says DREADD and its innovation from J. Craig Venter is equivalent in military and technical impact to Nuclear Bombs. I’m taking him seriously. These techniques apply to COVID vaccines!

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Holobiont Theory (Lynn Margulis et al) from Wikipedia:

“A holobiont is an assemblage of a host and the many other species living in or around it, which together form a discrete ecological unit,[1] though there is controversy over this discreteness. The components of a holobiont are individual species or bionts, while the combined genome of all bionts is the hologenome. The concept of the holobiont was initially defined by Dr. Lynn Margulis in her 1991 book Symbiosis as a Source of Evolutionary Innovation,[1] though the concept has subsequently evolved since the original definition.[2] Holobionts include the host, virome, microbiome, and other members, all of which contribute in some way to the function of the whole.[3][4] Well-studied holobionts include reef-building corals and humans.[5][6]

Overview

A holobiont is a collection of species that are closely associated and have complex interactions, such as a plant species and the members of its microbiome.[1][7] Each species present in a holobiont is a biont, and the genomes of all bionts taken together are the hologenome, or the “comprehensive gene system” of the holobiont.[8] A holobiont typically includes a eukaryote host and all of the symbiotic viruses, bacteria, fungi, etc. that live on or inside it.[7]

Holobionts are distinct from superorganisms; superorganisms consist of many individuals, sometimes of the same species, and the term is commonly applied to eusocial insects.[9][10] An ant colony can be described as a superorganism, whereas an individual ant and its associated bacteria, fungi, etc. are a holobiont.[8] There is no doubt that symbiotic microorganisms are pivotal for the biology and ecology of the host by providing vitamins, energy and inorganic or organic nutrients, participating in defense mechanisms, or by driving the evolution of the host.[11][12] There is still some controversy surrounding these terms, and they have been used interchangeably in some publications.[6]

Holobiont components

Host: The host member of a holobiont is typically a multicellular eukaryote, such as a plant or human.[8] Notable hosts that are well-studied include humans,[13] corals,[5] and pine trees.[14]

Microbiome: The microbiome includes bacteria,[3] archaea,[15] microscopic fungi,[7] and microscopic protists.[3] 

Virome: All of the viruses included in a holobiont are collectively referred to as the virome[16]

Fungi: Multicellular fungi can be included in holobionts, such as arbuscular mycorrhizal fungi (AMF) in the roots of plants.[7][4]

Plants

Although most work on host-microbe interactions has been focused on animal systems such as corals, sponges, or humans, there is a substantial body of literature on plant holobionts.[19] Plant-associated microbial communities impact both key components of the fitness of plants, growth and survival,[4] and are shaped by nutrient availability and plant defense mechanisms.[7] Several habitats have been described to harbor plant-associated microbes, including the rhizoplane (surface of root tissue), the rhizosphere (periphery of the roots), the endosphere (inside plant tissue), and the phyllosphere (total above-ground surface area).[12] The holobiont concept originally suggested that A significant fraction of the microbiome genome together with the host genome is transmitted from one generation to the next and thus can propagate unique properties of the holobiont”.[20] In this regard, studies have shown that seeds can play such a role. Evidence of this process have been recently proven showing that the majority, up to 95%, of the seed microbiome is mistranslated across generations.[21]

 The plant holobiont is relatively well-studied, with particular focus on agricultural species such as legumes and grains. Bacteria, fungi, archaea, protists, and viruses are all members of the plant holobiont…”

Read more: https://en.wikipedia.org/wiki/Holobiont

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‘Smokin’ Genius’

*There’s no doubt to these famous smokers that the Nicotinia species made a contribution. According to a ‘parkdale brass’ article: “Pipes allow people to transcend and connect with realms beyond our own to acquire knowledge and valuable insight… Jean-Paul Sartre seemed to think that smoking was a way of possessing the world and that the universe existed purely as something to be experienced while smoking… Bertrand Russell even said that pipe smoking saved his life…” https://parkdalebrass.com/blogs/news/powerful-people-and-smoking-pipes

Tobacco’s contribution of interest, whether by smoking or not, is this molecule: NAD+, essential to oxygen metabolism (redox), LIFE as we know it and civilization as we built it.  I’m learning the lack of NAD+ is the common denominator among people medically diagnosed with COVID and its oxygen deficient sequelae, called Long Covid. My particular concern is on the bio-nanotech devices that appear to co-opt  NAD+ and interfere with our all-important redox and Kreb’s cycle processes. To my knowledge at this point, tobacco and its derivatives (which may include ‘tobo’ viruses)are the only source of NAD+.

Nicotinamide adenine dinucleotide

https://en.wikipedia.org/wiki/nicotinamide-adenine-dinuceotide

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Oldest Known Evidence of Tobacco Use in North America Found in Ice Age Hunting Camp

…. “the most interesting part of the discovery is that there is no direct evidence that people used tobacco past 3,000 years ago, but this research proved its use more than 12,000 years ago.”

https://www.ancient-origins.net/news-history-archaeology/oldest-known-evidence-tobacco-use-north-america-found-ice-age-hunting-camp-020922

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Egyptian Life after Life

Tobacco leaves and beetle found in the mummy of Rameses II:  “The high levels of nicotine in Egyptian mummies, compared with other sources (Balabanova et al. 1997), have been interpreted as the result of the use of Nicotiana in the embalming process, something which could be supported by the Rameses evidence. Whilst the possibility of sources in plants other than tobacco, or the previous existence of Old World species of Nicotiana is considered (Balabanova et d. 1995), early importation from the New World is the explanation most favoured…” https://www.researchgate.net/publication/273292800_Rameses_II_and_the_tobacco_beetle

Can we suppose the tobacco “oxygen battery” (NAD+) was known and thought of  by the Egyptians as a regenerating medicament and escort to the realm of the eternal?

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Planting Viruses –From Plants! starts here https://jenniferlake.wordpress.com/2021/01/15/planting-viruses-from-plants/

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April 14, 2021

Project POSSESSION

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Originally published by Modern War Institute June 2018 https://mwi.usma.edu/mwi-video-dr-charles-morgan-neurobiology-war/

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“What’s going on is you’ve co-opted the hand[s] of another human… The really fun part is that you’re taking over somebody else’s physical body with the mind of another human.” [min15]

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“What we’re looking at is human [to] human thought transference… the brain-to-brain thought transference between two humans [and] they’ve achieved a success rate of 85% of the time. So you can attach…one human brain to another human brain; you can direct motor activity or you can send communication and information… There’s a whole world out there of biohacking… [min20]

“I think right now…the most direct application [of thought transference] is going to be either covert communication or running [biological and mechanical] drones. The set of experiments I didn’t have videos to show you [are] a series where you can connect a human brain to a rat and control its motor movement and its tail, so you can have nonhuman anima drones. You can have a human brain run a regular drone [already] at this point, but running a nonhuman drone…would be awesome… [min26] The software is now readily available where you could have hordes of creatures that can gain access to facilities or move around in different places all run by a person sitting in a booth. It’s no more logistically technical than learning how to send your signal anywhere in the world and protect that signal. That’s Now –it’s not in the future. As they refine transcranial magnetic stimulation…you can get ‘point’ specificity on the neurons you want to activate… [and] you should be able to do this with just visual stimulation to the retina.”

“Related to [medicine and individualized drugs] is DREADDs; Designer Receptors that can be remotely controlled – You can design a [cell] receptor, create a cell, put it somewhere in the body and you can remotely activate it when the brain is exposed to the right signal. Using this technology, people have been able to transfer memories from one fruit fly to another by signaling through a light stimulus into the retina. Right now [2018],  in most animals it’s done by putting a substance into the body that will actually activate the neurons in the way that you want it. So [with DREADDs] you have the capacity to create any [biologically synthesized] product as long as you know the DNA sequence and insert it into a living system and you can remotely control it.”

“When you create a cell and put it in somebody’s body, you have to figure out where you want it [to go]—what if you want it in their brain, right? And..you don’t want to do surgery to plant it in their brain to affect the way [they] think and act [then the] route to that is through stem cells… They call them God cells –they can turn into anything…unlike other cells in your body to become anything you want them to become and they can go find their home in the body and park there and do the work that you’d ike them to do. [ Power point shown “Mesenchymal stem cells: Infused peripherally can access brain tissue” Linan Liu et. al. 2013] So once you know the technology is [here] to edit, splice and program the cell and the technology currently exists to administer it… you can have things activated in other peoples’ brains. You can have the timed release of information on demand.

“DNA encryption –and it’s quite important– …I’ll just say the short story on this [is] people have figured out how to hide imagery in the DNA of bacteria and when you phosphoresce the bacteria you can discover the information or you can have the information reproduced in string form, the form of a protein. Dr. [George] Church up at Harvard has shown quite well that you can store a lot of information in one gram of DNA… at room temperature…for a very long time. So between CRISPR [developed by Church], storage capacity and programming cells, the new way to hide information is going to be in DNA… Why would you have a digital system when you can have a DNA system to store all the information you’ll ever need –photos, records, everything… You can hide information in bacteria and when the bacteria multiply they can go into spore form and last for a very long time. No one can scan you and find a bacteria. We don’t have anything that can detect that, so if you want to encode information… [in] DNA, and you don’t want it in your own body…[you get it back if] you scrape it [off], put it in a dish and unpack the information. This is all available now. This isn’t science fiction. [min33-37]

“So, what to do with memory. In medicine we think of memory as a potentially harmful thing when people present with post-traumatic stress disorder….   It’s a very active [area of] development in the field if we can erase memory; can we modify memory, can we change memory. The short answer is YES. [The PKMzeta method at Duke Univ.] was the first time anyone ever demonstrated that if you wash an area of the brain that’s crucial for forming memories –spatial memories and facilitating the transfer of short-term memory…to something..more permanent and stable over time—[you] can flood the hippocampus… and the memory will be completely gone…[and] there’s no trace of the memory left…  [min40] The hippocampus sounds impossible to get to [but] not if you program a cell to go there…[and] selectively release PKMzeta… [The] technical challenge right now is how do we get a cell in there to do that in a human. I can assure you they’re working on humans and not primates right now… [to] get it in there close enough to the hippocampus…[to] make enough of [itself] to wipe out a memory.

“Related to this are chemicals that not only wipe out memory but chemicals that enhance it… So, if you want a better human camera…, an individual who can…see and remember everything, that’s the direction…from a security and intelligence point [of view that] is a really unique opportunity… but it seems to be a harder nut to crack on enhancing memory than erasing memory [which] is far easier…

[But] I’ll remind you… [we] can train a fruitfly with an aversive memory and transfer that memory [to one that] never had that experience…and [it] reacts to the [averse memory] stimulus in the same way as the animal that did have the aversive learning experience. It’s been done in mice…[min44]

“In 2009, using light [they] transferred memory. You can turn things ON and OFF using light in animals to activate the hippocampus –turn memory ON and OFF [with a light ‘switch’]… the chemical implanting of memories has now occurred in monkeys. So, in the next two years we should actually see… a memory implanted [chemically] into a human brain…[min51]

…”There’s gonna be a HIVE brain, it’s already been done in rats…link[ing] multiple brains, and as a HIVE they solve…problems much faster than an individual rat. That technology’s here. I’m assuming [DARPA] will link people [so they can] live in virtual reality, move things and problem solve, so in the next few years that’s what I think we’ll see… It’s really no longer science fiction.”

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For more (from the past) see ‘Threat Tech –Neuroweapons https://jenniferlake.wordpress.com/2016/06/05/threat-tech-neuroweapons/

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March 2, 2021

DNA computers

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What a Technocracy needs: infinite data storage

“…DNA storage has been estimated to have a longevity of 2,000 years.” [2016 article about Microsoft and Twist Bioscience, linked below]

 

2017, Dina Zielinski TED talk : “All the World’s Data in DNA”   https://www.ted.com/talks/dina_zielinski_how_we_can_store_digital_data_in_dna

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“As humanity creates more and more digital data, archiving the information on hard drives presents economic and ecological challenges. Today an ever-expanding network of large data-storage centers already accounts for more than 2 percent of all electricity consumption in the United States.

“In an effort to develop cheaper and more sustainable storage methods, some scientists have begun experimenting with putting data onto nature’s original hard drive: DNA. In the past five years, a number of research groups have shown that synthetic forms of DNA can be encoded with words, images, or music just as easily as with biological information.

“Now [2017] Yaniv Erlich, an assistant professor of computer science at Columbia Engineering, and Dina Zielinski, a bioinformatics researcher at the New York Genome Center, have achieved a major breakthrough in this area, developing a technique that has enabled them to fit 60 percent more digital data onto a given strand of DNA than was previously possible. In a recent issue of the journal Science, the researchers describe how they managed to squeeze a trove of digital content — including a copy of the 1895 Lumière brothers film Arrival of a Train at La Ciotat, a full computer operating system, a $50 Amazon gift card, a computer virus, and a 1948 study by information theorist Claude Shannon — onto a speck of DNA so small that if it existed in a living organism, it would likely carry the blueprints for just a handful of proteins [like a virus]. They say that their technique could theoretically enable scientists to cram millions of megabytes of information onto a single gram of DNA.

“To the best of our knowledge, this is the highest-density storage device ever created,” says Erlich.

Erlich and Zielinski’s storage technique is also very reliable. The researchers say that even after they induced the DNA to make copies of itself, and then forced those copies to make copies, and so on, the resulting double helices were found to contain flawless replicas of the original data.

“ ‘We really tortured the content to see if there was anything we could do to make errors appear,’ Erlich says. ‘But each time we read the files back onto our computers, they worked perfectly.’

“Downloading data onto DNA is still too expensive for commercial use; it cost Erlich and Zielinski about $9,000 to store and retrieve theirs. But the researchers suspect that if they and other scientists can continue to improve the efficiency with which they translate computer code, with its long strings of 0s and 1s, into the chemical language of DNA, made up of various combinations of the four nucleotides adenine (A), guanine (G), cytosine (C), and thymine (T), the strategy could eventually provide a cost-efficient option for archiving everything from Facebook posts to historical documents.”

https://magazine.columbia.edu/article/future-data-storage-our-dna

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“How We’re Building the World’s Largest Family Tree” –Yaniv Erlich, 2018– https://www.ted.com/talks/yaniv_erlich_how_we_re_building_the_world_s_largest_family_tree/transcript

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“Team Erlich” report [2017] on their DNA storage retrieval:

…”Recent studies have made large strides in developing DNA storage schemes by exploiting the advent of massive parallel synthesis of DNA oligos and the high throughput of sequencing platforms. However, most of these experiments reported small gaps and errors in the retrieved information. Here, we report a strategy to store and retrieve DNA information that is robust and approaches the theoretical maximum of information that can be stored per nucleotide. The success of our strategy lies in careful adaption of recent developments in coding theory to the domain specific constrains of DNA storage. To test our strategy, we stored an entire computer operating system, a movie, a gift card, and other computer files with a total of 2.14×106 bytes in DNA oligos. We were able to fully retrieve the information without a single error even with a sequencing throughput on the scale of a single tile of an Illumina sequencing flow cell. To further stress our strategy, we created a deep copy of the data by PCR amplifying the oligo pool in a total of nine successive reactions, reflecting one complete path of an exponential process to copy the file 218×1012 times. We perfectly retrieved the original data with only five million reads. Taken together, our approach opens the possibility of highly reliable DNA-based storage that approaches the information capacity of DNA molecules and enables virtually unlimited data retrieval.” https://www.biorxiv.org/content/10.1101/074237v2

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“They [Team Erlich] say DNA Fountain, so named because it uses fountain codes, which are used for video streaming to mobile devices ‘approaches the Shannon capacity while providing robustness against data corruption’.  According to Science Daily, they used DNA Fountain to generate 72,000 DNA strands or oligos that were sent to Twist Bioscience, the DNA synthesis firm that supplied Microsoft’s synthetic DNA…  As the researchers highlight, DNA storage in this study cost $3,500 per megabyte. However, they see the cost falling with improvements to DNA synthesis chemistry, as well as ‘quick-and-dirty oligo synthesis methods’ that consume less machine time.” https://www.zdnet.com/article/dna-data-storage-landmark-now-its-215-petabytes-per-gram-or-over-100-million-movies/

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https://en.wikipedia.org/wiki/New_York_Genome_Center

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Yaniv Erlich is an Israeli-American scientist. He is an Associate Professor of Computer Science at Columbia University and the Chief Science Officer of MyHeritage… Erlich was born in Israel. He earned BSc in Brain Sciences in 2006 from Tel Aviv University and a PhD in bioinformatics in 2010 from Watson School of Biological Sciences at Cold Spring Harbor Laboratory. From 2010 to 2015, Erlich was a Fellow at the Whitehead InstituteMIT. Since 2015, he leads a lab at Columbia University in computational genomics  https://en.wikipedia.org/wiki/Yaniv_Erlich

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“…DNA storage has been estimated to have a longevity of 2,000 years.” https://www.zdnet.com/article/microsoft-buys-10-million-dna-molecules-to-try-fitting-todays-sprawling-data-vaults-on-a-match-head/

DNA Data Storage Alliance Launches With Illumina …

https://www.bio-itworld.com/news/2020/12/01/dna-data-storage-alliance-launches-with-illumina-microsoft-twist-bioscience-western-digital

By Bio-IT World Staff December 1, 2020 | Twist Bioscience Corporation, Illumina, and Western Digital announced an alliance last month with Microsoft to advance the field of DNA data storage.

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Illumina is mentioned here: previous blog post ‘Biology is Nanotechnology’

https://jenniferlake.wordpress.com/2021/01/13/biology-is-nanotechnology/

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“DNA is an incredible molecule that, by its very nature, provides ultra-high-density storage for thousands of years,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience…  By 2024, 30% of digital businesses will mandate DNA storage trials, addressing the exponential growth of data poised to overwhelm existing storage technology…   DNA Data Storage Alliance plans to develop use cases in various markets and industries as well as promote and educate the larger storage community to promote adoption of this future solution…

About Illumina

Illumina is …the global leader in DNA sequencing…

About Western Digital

Western Digital creates environments for data to thrive. As a leader in data infrastructure, the company is driving the innovation needed to help customers capture, preserve, access and transform an ever-increasing diversity of data… Our data-centric solutions are comprised of the Western Digital®, G-Technology™, SanDisk®, and WD® brands.

About Twist Bioscience Corporation

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries…” https://investors.twistbioscience.com/news-releases/news-release-details/twist-bioscience-illumina-and-western-digital-form-alliance

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February 21, 2021

Packing For The Millenium

Filed under: 1 — jenniferlake @ 5:04 pm
Tags: , ,

Earthships and Cob

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https://earthshipbiotecture.com/amazing-new-earthship-video-with-drone-footage/

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Starting small with cob –lumps of clay-sand-straw– for the ultimate inexpensive DIY to multistory towers and other flights of imagination

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Cob coming together

Building a wall in Wisconsin  https://www.youtube.com/watch?v=FZS2ZEN2bTs

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Timber and cob coming together for 3 weeks  https://www.youtube.com/watch?v=gVFlkejVE8A

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Cob house and family homestead  https://www.youtube.com/watch?v=J94TqEEPp1I&feature=youtu.be

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Improving conditions

Allan Savory – grazing cattle restore gardens and grasslands https://www.youtube.com/watch?v=q7pI7IYaJLI

Brad Lancaster — harvesting rainwater in Tuscon https://www.youtube.com/watch?v=KcAMXm9zITg

Bjorn Lomborg — social scientist looks at real world fire, flood, and climate facts with cost/benefit projections  https://www.youtube.com/watch?v=otsJno55J0g

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February 15, 2021

Ancient Egyptian Secrets: Poured Concrete and Circumnavigation

Filed under: 1 — jenniferlake @ 4:47 pm

My added preface here is to state that ancient concrete and circumnavigation are ‘no-brainers’. The makers of this film apparently do not embrace any part of the ‘Forbidden Archaeology’ premise promoted by Michael Cremo and Richard Thompson that homosapiens have been around using advanced technologies for millions of years.  The contradictions inherent in rejecting ‘extreme’ human antiquity are best demonstrated in this film by juxtaposing the ‘lens’ method of concrete smelting (which is interesting!) with the hand-to-hand ‘bucket brigade’ building technique. Silly! If you watch it, skip ahead and save lots of time.  Here are two worthwhile programs featuring Michael Cremo:

1996 (NBC orig. on tv) “Mysterious Origins of Man” https://www.youtube.com/watch?v=u__Zm4stnug

2017 Michael Cremo at the Origins conference https://www.youtube.com/watch?v=m-TKhEYe03M

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Shown in The Pyramid Code, quartz blocks with smooth parabolic basins at Saqqara — lens molds?

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February 3, 2021

Making and Faking Viruses

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*image of ‘viruses’ in seawater sample

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This post is a “cut to the chase” about the War Upon You – the uncomplicated version of context—drawn forward from the Big Science coup d’etat of World War Two and our cultural entry into the Nuclear/Space Age. The Big Science of biology and genetics goes from “Tobacco Mosaic Virus to Coronavirus” in my review Planting Viruses, as an intertwining parallel to the high-energy technology that brought nuclear missiles, satellites and global communications to the planet.  Radiation, whatever its source, is a biological weapon outside of the limited compatibility range in which we evolved. Radiation co-factored with chemistry –specifically biochemistry— is the basis of Life as we know it. Radiation and chemicals together makes, unmakes, and remakes the living world. Edward Teller, “father of the hydrogen bomb”, remarked that his weapons would “change mankind’s relationship with the universe”. Despite his own chronic health problems related to his work, Teller maintained that “radiation is good for you.”

The very “fine forces” that hold us together as living beings are electro-chemical bonds (not ‘flesh and blood’ per se) under constant over-riding assault from ‘technology’, be it frequencies, gmo foods, medicines, pollutants and the rest. That said, Planting Viruses is following the trail of documentation from TMV to CoV to show how public attention has been diverted away from the real causes of modern epidemics to the pseudoscientific Germ Theory of disease by way of planting viruses from plants! It’s a big, slow story in need of a Teller, you could say, to give it impact —  but a great deal of the evidence is straightforward at the laboratory level. Scientific “maker” culture reduces all to its smallest irreducible parts and “rebuilds” –  “build back better” as we hear it said today, applied to everything that defines us.  Planting Viruses is just one more Lost Chapter in the theft of our humanity, demonstrated here by the breaking of species barriers. Among the questions raised and addressed is the proposition that ‘universal’ polio vaccines of the 1950s were loaded with plant genes and propagated on substrates bearing plant genes, like Hela cells harboring Tobacco Mosaic Virus. The poliovirus, for all the world, is a plant.

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Keep this in mind:

“It’s raining viruses, but don’t panic” (published 2018)

https://www.pri.org/stories/2018-03-09/its-raining-viruses-dont-panic

[article excerpt]

“Viruses and the organisms they infect are extremely highly coevolved,” Suttle explains, “and as part of that process, viruses are really, really good at moving genetic information around. In fact, the field of biotechnology originated [with the discovery] that you could use a virus to move genetic information from one organism to another. The original genetic engineering, if you like, was using viruses to actually move genes around among organisms.”

A large percentage of human nucleic acids — our DNA — is actually viruses that are “still stuck in our genome,” Suttle points out. The placenta of mammals contains a protein that was donated by viruses; major components of our nervous system are the result of genetic information donated from viruses. “Viruses are masters at moving genetic information around and, as a result of that, they’ve been absolutely crucial to the evolution of all organisms,” he says. [end except]

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“Synthetic viruses: a new opportunity…” (published Dec.2009)

“Rapid progress in DNA synthesis and sequencing is spearheading the deliberate, large-scale genetic alteration of organisms. These new advances in DNA manipulation have been extended to the level of whole-genome synthesis, as evident from the synthesis of poliovirus, from the resurrection of the extinct 1918 strain of influenza virus and of human endogenous retroviruses…”  https://pubmed.ncbi.nlm.nih.gov/20010599/

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Polioviruses are “Members of the family Picornaviridae (genus Enterovirus) and of the family Secoviridae (genus Comovirus) were the first characterized members of the order and infect vertebrates and plants, respectively. The order also includes viruses infecting invertebrates (families Dicistroviridae and Iflaviridae) or algae (family Marnaviridae). Large-scale environmental genomic studies suggest the presence of a large number of uncharacterized picorna-like viruses in the ocean.” https://www.sciencedirect.com/science/article/pii/B9780123846846000707

“The poliovirus is capable of producing an encephalitis, with or without symptoms, in the absence of any damage to the spinal cord. As far as the pathologist is concerned all cases of polio are encephalitic”.[p21] It’s amazing that something so small can do so much damage…But the poliovirus doesn’t attach to and damage just any cell. It is a ‘guided missile’ that does one thing: seek out, damage, and destroy the neurons that “activate” you –the ones that activate your brain and muscles. The poliovirus is the perfect human “Off switch”… https://polioforever.wordpress.com/post-polio/

The author of those words, Richard L. Bruno in The Polio Paradox, appears to sincerely believe in the vaccine prevention of polio and writes nothing about the radiation and chemical cause of polio-like disease, a newly immanent crisis in the United States as the country emerged from World War II and catapulted into the Nuclear Age. Doctors in the 1940s attempting to ‘isolate’ poliovirus (serum) from polio patients were overwhelmingly unable to find the infectious agents.  The mandate to prevent polio with a ‘cure’ in the era of radioactive fallout seems incentive enough to “plant” a virus and use the vaccine in a new kind of “vaccine diplomacy” among nuclear-armed nations.

* Mahoney Type 1 poliovirus

 

The “wild” Mahoney type 1 poliovirus was collected and filtered into solution “virus” in 1941 by Dr. Thomas Francis of the Rockefeller Hospital. Personal physician to the Rockefeller family, Dr. Francis at the time had been newly set up at the University of Michigan on U.S. Army business in the capacity of  a public health laboratory. The Mahoney sample came from the pooled feces of three Cleveland area siblings who were asymptomatic –healthy!—and became the “type species” (first to be discovered) of the picornaviruses, or “prototype” as Eckard Wimmer noted in his 2002 created-from-scratch documents. The Mahoney strain procured in the lab, it turned out, was the deadliest of the recent polio filtrates. Work on another new polio vaccine, ongoing since the 1930s, however, was delayed;  Thomas Francis and his collaborator Jonas Salk were set on the task of making an influenza vaccine during the war. Clinically observed as sickness, there was no difference between polio and flu, but polio was to retain its distinctively special character as “infantile paralysis”—by then, a political definition of great value. All “influenza-like” disease, we now know, can be produced from exposure to radiation and chemicals.

Down Under in Australia’s city of Melbourne, Frank McFarlane Burnet was set on the same task of making an influenza vaccine for his government in WWII, to which he had also recommended the making of bioweapons in the form of intestinal agents. Burnet favorably selected influenza virus over the poliovirus for influenza’s quality of stability in lab experiments –having a larger genome it was less likely to mutate out of existence as poliovirus would were it not for vaccination and revaccination.

Contemporary  investigations reveal that plant viruses are normal commensals of the human gut, as they should be, able to be collected and reconstituted from newborn, exclusively breast-fed infants. In a very small but significant study, modern observers noted that 17 plant viruses were collected from newborn human feces, including tobacco mosaic virus, the “type species” of the helical rod, filamentous group. None of the parents of these newborns used or worked with tobacco, although it is known that TMV ‘infects’ many hundreds of plant species, including the most valuable food crops and flowers. Tobacco Mosaic Virus is the first virus, the prototypical “filtrate” substance obtained and ‘confirmed’ as a disease agent in 1892.  With this tobacco virus “tool”, I propose to demonstrate how TMV mutants and by-products became the “vaccine” viruses of modern allopathic practice.

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Eckard Wimmer, the elderly researcher who created poliovirus from scratch: …”My favorite virus is poliovirus… and in 2002 we published a paper that we had recreated the virus from information on the internet and no virus was necessary…. This was an enormous shock…[because] the parent of this virus…was the computer.”

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“Originally trained as an organic chemist, Wimmer developed a deep understanding and fascination for viruses as replicating (living) biological entities as well as (non-living) aggregates of organic compounds, or, “as chemicals with a life cycle”.[2][3] After working on the structure of tRNAs and the structure of a plant RNA virus (satellite tobacco necrosis virus), Wimmer chose to study poliovirus in 1968. Poliovirus is the cause of the horrific disease poliomyelitis, which can cause irreversible flaccid paralysis and even death. Neither the molecular biology of poliovirus proliferation nor the mechanism of its pathogenesis was understood in the nineteen sixties…  Using the nucleotide sequence of the genome deciphered in 1981, Wimmer followed up on the work published in 1991 by synthesizing chemically the genome in the form of double stranded DNA (“cDNA”), which was then transcribed enzymatically[16] into genome RNA and “booted to life” in the cell free system.[3] This work, published in 2002 by Cello, Paul and Wimmer, was the first test-tube synthesis of an organism in the absence of a natural template achieved outside living cells.[3] The poliovirus synthesis caught global attention, high praise, ridicule and fierce condemnation…” https://en.wikipedia.org/wiki/Eckard_Wimmer

Wimmer’s company : CODAGENICS, is shopping its corona vaccine

“Starting from only viral sequence data (no physical virus), Codagenix can routinely design, construct, and grow multiple live-attenuated vaccine candidates ready for animal safety and efficacy testing in less than one month, and faster if needed as new outbreak strains are identified… We seek to upend the current approach to making live-attenuated vaccines”… https://codagenix.com/vaccine-programs/pipeline/

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In reality… “Except for a few cases, viruses are not surrounded by a membrane. If present, the membrane around a virus particle – as seen in electron microscopic images – stems usually from the host cell. Viruses have no energy metabolism of their own. Consequently, they cannot perform syntheses and are thus unable to replicate themselves…  With plant viruses, the term specificity (or host-specificity) has a very narrow meaning, since no plant virus as such exists….” http://www1.biologie.uni-hamburg.de/b-online/e35/35.htm

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“All viruses are good viruses”…”they are solvents”….”[and] the only way [people] can get a swine flu or a bird flu is if [it] is injected in them” –Aajonus Vonderplanitz, PhD

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From Stefan Lanka: Pathogenic, disease-causing “Viruses Don’t Exist” http://www.youtube.com/watch?v=NU9f3Vc67oE

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Planting Viruses is a series-in-progress. So far, part three is currently under construction out of a probable five or six. When I finish it, I’ll be back to this spot to post a summary of each segment.

It starts here:  https://jenniferlake.wordpress.com/2021/01/15/planting-viruses-from-plants/

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