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Can ‘normal’ children be born with ‘old’ diseases? Longevity research which lumps Alzheimers and atherosclerosis together with inflammatory asthma, for example, suggests they can by focusing on the role of NAD-dependent sirtuins: “[Sirtuins] mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis, and asthma.” –p24, Lifespan, by David Sinclair, 2019
I once overheard two new mothers pushing their baby strollers past my house and chatting loudly during their early-morning workout: “But the doctor said he was born with asthma!” said one. “Not only that but, did you know…” said the other, and the conversation trailed off with them as they moved. My mind fixed on the words ‘born with asthma’. This was 10 years ago and I still haven’t found a mainstream citation to support the claim, though admittedly not looking hard for it. Asthma, they say, is caused by viruses, and babies indeed are born with those — apparently born with a variety of tobacco-type viruses (tobamovirus) in their guts which increase in the first year of life to as much as 50% of viral content in the gut biome as they near age 2.
Tobamoviruses come from plants, it is assumed. Vectors known today include any number of members from all the Life kingdoms.
Asthma, at face value:
Asthma in Children: Risk Factors, Diagnosis, Management
https://my.clevelandclinic.org/health/diseases/6776-asthma-in-children
Asthma is the leading cause of chronic (long-term) illness in children. It affects more than 7 million children in the United States. For unknown reasons, the rate is steadily increasing. Asthma can begin at any age, but most children who have it have their first symptom by age 5.
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Childhood asthma – Symptoms and causes – Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/childhood-asthma/symptoms-causes/syc-20351507
In childhood asthma, the lungs and airways become easily inflamed when exposed to certain triggers, such as inhaling pollen or catching a cold or other respiratory infection. Childhood asthma can cause bothersome daily symptoms that interfere with play, sports, school and sleep.
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Asthma in Infants | AAFA.org
https://www.aafa.org/asthma-in-infants/
Some preschool children get viral infections often. At least half of children with asthma show some sign of it before the age of 5. Viruses are the most common cause of acute asthma episodes in infants 6 months old or younger. How Is Asthma in Infants and Toddlers Different Than Adult Asthma?
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Viral Infections and Associated Factors That Promote Acute …
https://pubmed.ncbi.nlm.nih.gov/29178673
Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway microbiome. Once asthma is established, acute exacerbations are usually associated with infections with respiratory viruses, such as rhinoviruses (RVs)…
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Rhinoviruses are identical to polioviruses, which in turn are identical to certain plant viruses –read on to citation “Can Plant Viruses Cross the Kingdom Border and Be Pathogenic to Humans.”
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[2009] Bugs and asthma: a different disease?
“The prevalence of asthma has dramatically increased in recent decades. Exacerbations of asthma are a large contributor to asthma-related costs, and are primarily caused by viral and atypical bacterial infections. Rhinoviruses (RVs) are the most common viruses detected after an asthma exacerbation. RVs, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) viral infections early in life can induce wheezing and are associated with the development of asthma later in life. Atypical bacterial infections from Mycoplasma pneumoniae and Chlamydia pneumoniae have also been linked to chronic asthma and potential asthma exacerbations. In this article, we will discuss recent developments in viral infections, specifically RV, RSV, and hMPV, and atypical bacterial infections as causes of asthma…” https://pubmed.ncbi.nlm.nih.gov/19387028/
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Life in the Virosphere
Longevity molecules are being discovered in “Plants experiencing stress”—from Lifespan: “[R]esveratrol is produced in greater quantities by grapes and other plants experiencing stress. We also knew that many other health-promoting molecules, and chemical derivatives of them, are produced in abundance by stressed plants; we get resveratrol from grapes; aspirin from willow bark, metformin from lilacs… Plants have survival circuits too, and we think we might have evolved to sense the chemicals they produce in times of stress as an early-warning system, of sorts, to alert our bodies to hunker down [in ‘protection’ mode] as well. What this means, if it’s true, is that when we search for new drugs [or new microbes] from the natural world we should be searching the stressed-out ones: in stressed plants, in stressed fungi, and even in the stressed microbiome populations in our guts. The theory is also relevant to the foods we eat; plants that are stressed have higher concentrations of xenohormetic molecules…” –p131, ibid.
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“Hormesis is a characteristic of many biological processes…[in] response to exposure to increasing amounts of a substance or condition…[and is] generally a favorable biological response to low exposures to toxins and other stressors. The term hormesis comes from Greek hórmēsis “rapid motion, eagerness”, itself from ancient Greek hormáein “to set in motion, impel, urge on”… https://en.wikipedia.org/wiki/Hormesis
—in other words, accelerating stress.
“This review compiles information on how hormesis in plants can be used to achieve new production levels… [by application of pesticides, such as glyphosate, where]..the plants benefit from a low dose whereas are distressed by a high dose which leads to an irreversible and negative outcomes on the health and functions of plants” https://www.sciencedirect.com/science/article/pii/S0147651320310642
Directing hormetic activity by inducing stress ‘toxins’ with chemicals and radiation particularly, is a controversial practice, not to mention other “trauma-based hormesis.” Largely from insights on what is posted here, hormetic “stress chemicals” produced in response to change are another addition to the category of ‘virus’ .
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The dominant ‘birth’ virus identified in the Nature article below (Aug.2020) and drawn from a small study in 2016, showed Pepper Mild Mottle Virus (PMMoV) as the most abundant ‘reconstructed’ genome, but the classic ‘type species,’ Tobacco Mosaic Virus (TMV) was also found in these infants, though their parents neither smoked nor handled tobacco. By size and shape, PMMoV and TMV are identical. TMV, in rod form, can be extracted from many hundreds of common food plants. There are also disc, ring, and spherical virions of TMV, but that subject will be explored in the next installment (#4) of Planting Viruses—to some extent, already posted in #3.
[2009]…” Typical tobamovirus-like particles (rigid rods ≈300 nm long) were observed in crude plant extracts. According to literature, at least six tobamoviruses infect peppers: Paprika mild mottle virus (PaMMV); Pepper mild mottle virus (PMMoV); Ribgrass mosaic virus (RMV); Tobacco mild green mosaic virus (TMGMV); Tobacco mosaic virus (TMV); and Tomato mosaic virus (ToMV)” … https://pubmed.ncbi.nlm.nih.gov/30764375/
New ‘pepper’ tobamoviruses have recently been discovered [2008] and this citation is relevant to my grocery shopping—the packaged peppers on my area’s food shelves are imports from Israel.
[2008] “The biological, serological, and molecular characteristics of a newly isolated L4 resistance-breaking isolate of Pepper mild mottle virus (PMMoV) were studied. The new pathotype of PMMoV is closely related to the Israeli pathotypes P1,2 and P1,2,3 of the virus; however, the mosaic symptoms caused by this new pathotype on pepper plants with an L4 genotype were more severe than the mild mosaic symptoms caused by other common pathotypes…” https://www.apsnet.org/publications/plantdisease/2008/July/Pages/92_7_1033.aspx
[2010] Pepper Mild Mottle Virus, a Plant Virus Associated with Specific Immune Responses, Fever, Abdominal Pains, and Pruritus in Humans
“Recently, metagenomic studies have identified viable Pepper mild mottle virus (PMMoV), a plant virus, in the stool of healthy subjects. However, its source and role as pathogen have not been determined…” https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010041
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[2015]
Can Plant Viruses Cross the Kingdom Border and Be Pathogenic to Humans?
…” Accordingly, plant viruses are not considered to present potential pathogenicity to humans and other vertebrates. Notwithstanding these beliefs, there are many examples where phytoviruses circulate and propagate in insect vectors. Several issues are raised here that question if plant viruses might further cross the kingdom barrier to cause diseases in humans. Indeed, there is close relatedness between some plant and animal viruses, and almost identical gene repertoires. Moreover, plant viruses can be detected in non-human mammals and humans samples, and there are evidence of immune responses to plant viruses in invertebrates, non-human vertebrates and humans, and of the entry of plant viruses or their genomes into non-human mammal cells and bodies after experimental exposure. Overall, the question raised here is unresolved…It is currently considered that phytoviruses only infect plants and therefore, plant viruses cannot cause disease in humans. In the present review, several issues are raised that challenge this paradigm.…”We describe here that some plant and animal viruses are closely related; humans are considerably exposed to plant viruses; plant viruses can enter mammalian cells and bodies and be naturally present in mammals, including humans; and this presence may be non-neutral; plant viruses may trigger events in mammalian cells and elicit immune responses in invertebrates, non-human vertebrates and humans, and was recently associated with clinical symptoms.
…”The distribution of plant and animal viruses within the currently defined taxons indicates that some plant and animal viruses belong to same viral families (Table 1)… This is true for family Reoviridae, which includes rotavirus, a major cause of gastroenteritis in humans [36], family Rhabdoviridae, which notably includes rabies virus [37], and family Bunyaviridae, which encompasses human pathogens such as Hantaan virus and Toscana virus [38,39,40]. Within the family Rhabdoviridae, genomic organization indicates that some plant viruses of genera Nucleorhabdovirus and Cytorhabdovirus differ from animal viruses of genera Vesiculovirus, Lyssavirus, Novirhabdovirus and Ephemerovirus only by the presence of an additional gene coding for a movement protein, a protein essential for the systemic spread of the virus in the host plant [17,18,37,41]….
…”In addition, Cowpea mosaic virus (CPMV), which is a member of family Secoviridae, shares structural features and genetic organization with animal picornaviruses such as polioviruses, coxsackie viruses and Theiler’s murine encephalomyelitis virus (TMEV), which supports the hypothesis that these plant and animal viruses might derive from a common ancestor [43,44]. In addition, pararetroviruses include plant viruses from the family Caulimoviridae, which consists of the only plant viruses with a double-stranded (ds) DNA genome, as well as animal viruses that belong to the family Hepadnaviridae, which includes hepatitis B virus [45]. Similarly, hepatitis E virus, a leading cause of acute hepatitis in humans, was grouped with Beet necrotic yellow vein virus, a plant virus that belongs to the genus Benyvirus, based on phylogeny of RNA polymerases [46]. Recently, endogenous viral elements (EVEs) from plant RNA viruses were detected in 14 insect genomes [47]. Interestingly, EVE sequences very close to those of phytoviruses of the family Virgaviridae were detected in the genome of a mosquito, Aedes aegypti; a fly, Drosophila rhopaloa; and a bee, Bombyx terrestris. The EVE detected in Aedes aegypti was similar to the tobamovirus genome, which is very surprising as no insect vector is known for tobamoviruses…”
https://www.mdpi.com/1999-4915/7/4/2074/htm
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NATURE magazine, August 2020
“In this work, we report that plant viruses can also be found frequently in the gut and oropharynx of children during their first year of life, even when they are exclusively breast-fed…
“In 100% of the fecal samples and 65% of the oropharynx samples at least one plant virus was identified. Tobamoviruses in the Virgaviridae family were by far the most frequently detected, with tropical soda apple mosaic virus, pepper mild mottle virus, and opuntia tobamovirus 2 being the most common species. Seventeen complete virus genomes could be assembled, and phylogenetic analyses showed a large diversity of virus strains circulating in the population. These results suggest that children are continuously exposed to an extensive and highly diverse collection of tobamoviruses…
“Metagenomic studies describing the composition of eukaryotic viruses in the gastrointestinal and respiratory tracts of children are limited, and only a few of them have included children under 1 year of age5,6,7,8,9,10,11. In addition, most of the reported studies have characterized the virome in diseased children8,9,10,11 and just a few have studied community-based healthy children5,6,7. Therefore, we aimed to determine the diversity and dynamic of the oropharyngeal and gastrointestinal eukaryotic viromes in [healthy] children under 1 year of age in a semi-rural population in Mexico, using next generation sequencing. In addition to human viruses, we found that plant viruses were commonly present in the gut and the oropharynx of children during their first year of life and, surprisingly, they were found as early as 2-weeks after birth in exclusively breast-fed infants. Tobamoviruses, in the Virgaviridae family, were the most abundant, and were present in most of the samples analyzed. Of interest, antibodies to plant viruses have been found in animals, including humans3, and it has also been shown that cowpea mosaic virus can disseminate systemically when orally administered to mice12. Whether the common presence of these viruses at an early age has an effect in the infant’s immune system and maturation of the gut remains to be investigated…
…”Some studies have detected the presence of Virgaviridae sequences in fecal samples of children with particular pathologies. Thus, in a study carried out in the Hunan province of China, 238 fecal samples were collected from pediatric patients (0–12.4 years of age) who were clinically diagnosed with mild or severe hand-foot-and-mouth disease10. In pools of samples from severe cases, 94% of the total viral reads were classified in the family Virgaviridae…
“It is now clear that the bacterial communities in the gastrointestinal tract play a critical role on different human developmental pathways early in life22. In this regard, it is of great interest the considerable exposure that infants can have to plant viruses during the first year of life, as shown by the high frequency of detection of tobamoviruses in both the oropharynx (65%) and fecal (100%) samples starting at least 2 weeks after birth. This raises the question of whether these viruses could have an impact in the maturation of the infant’s immune system or in their healthy development, directly or through interactions with other components of the microbiota, as has been observed for norovirus [Norwalk virus] in a mouse model23. This possibility needs to be investigated.”
(snip) https://www.nature.com/articles/s41598-020-70684-w
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This Nature study excerpted above, like all others purporting to study humans, makes Zero mention of the vaccination status of study subjects. Given its recent date though, it can and should be assumed that participants were vaccinated according to WHO/CDC recommendations. At the moment, Mexico exempts children under 18 from COVID vaccines unlike the U.S. which is now recommending CoVax for 6-month-old babies and pregnant women.
Routine shots for babies at birth in Mexico, now for longstanding, includes BCG (tuberculosis) and HepB. At 2-months they get Rotarix (rotavirus), anti-pneumococcal, and a whopping ‘pentavalent’ vaccine against H.influenzae, pertussis, diphtheria, tentanus and polio. At six months of age they start regular vaccines for influenza and polio (Sabin OPV and Salk IPV). At 12-months adding HepA, varicella (chicken pox) and Triple SRP (measles, mumps, rubella) –and after that, boosters as they grow, HPV at age eleven and so on. https://en.wikipedia.org/wiki/Vaccination_in_Mexico
Most of these vaccines would also have been given to the mothers when they were young and since 2012, pregnant mothers receive an additional Tdap. The ‘Nature’ study picks up its pregnant volunteers in the third trimester—after, presumably, getting their Tdap.
· Pregnancy and Vaccination: Why Maternal Vaccines Are …
http://www.cdc.gov › vaccines › pregnancy
“Tdap Vaccine Tdap vaccine is recommended during every pregnancy, between 27 and 36 weeks gestation (preferably earlier in this period). When given during pregnancy, Tdap vaccine boosts antibodies in the mother, which are transferred to her developing baby. Early third trimester administration optimizes neonatal antibody levels.”
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Before I launch my ‘stress chemical’ explanation for the presence of tobamoviruses in newborns, I’d like to share this complex description of the mRNA CoV vaccines from an interview between Joseph Mercola and Stephanie Seneff. Touching on a lot of points of virus interaction, this interview also has a beautiful illustration of how our bodies integrate RNA, reverse transcribe it to DNA and pass the genetic ‘signals’ (of more RNA and proteins) on to other cells, including sperm and egg cells.
https://articles.mercola.com/sites/articles/archive/2021/05/23/stephanie-seneff-covid-vaccine.aspx
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Minute 29—
Mercola: “You found that there is a lot of [naturally-existing] reverse transcriptase in our [cellular] DNA…and this causes our body to turn RNA back into DNA…
Seneff: “…we actually have plenty of reverse transcriptase in our own cells… and if these LINEs and SINEs are able to [convert] RNA back to DNA and to put that DNA back into the genome… and those [LINEs, “sometimes called ‘junkDNA’”] …surprisingly is 10% of our DNA… they’re really weird—they fold DNA and stick it in backwards and…do crazy stuff [that’s] so fascinating… And when people have Alzheimers…[for example] they get multiple copies of that amyloid beta protein…[as] extra genome, with variations in those copies [which] they [made] through RNA… It’s an evolution, and the mechanism from which we evolve, probably… So, we’re taking that RNA, mutating it –because RNA mutates much more easily than DNA does—and then [transcribing] it back into DNA and sticking it back into the genome… This is a known process associated with cancer and all these neurological diseases…
“And when you have [glyphosate, i.e.] with the body so sick [it’s] trying to mutate its way around those problems… It’s a process we use to try and deal with toxic chemicals in [our] environment…
Mercola: “…So,[mutations] can be transferred down genetically…like editing…
Seneff: “yes, and I was blown away to learn about the sperm… There’s a complete story in it that sperm can take… messenger RNA, external RNA and that can be from a virus or a vaccine, taking it in and converting it to DNA and then producing what’s called plasmids. So the sperm does this: whatever mRNA they come up with…,they make [into] plasmids…which is converted to DNA and put into these little pellets –and all the sperm [not just the ‘lucky’ one] in this [fertilizing] environment [around the egg]…are basically handing over to the egg all these plasmids with nuggets of RNA/DNA in them that they [picked up]… The egg takes it up and puts them into all the cells as it grows and… by the time the child is born, it’s got all these plasmids in there with…code to make [vaccine/viral] proteins… And now that child is not going to have any antibodies to that protein –its going to [detect only] human protein. It’s immune system is going to be trained that this is a natural protein and doesn’t need antibodies to it. So if that child gets exposed to [the corresponding] disease it’s immune system won’t react… and they’ll be able to carry that virus for their entire lives and pass it on down to their children…
…”Now, there is [a] disease that cows were getting—a diarrheal infection that was a problem—and what would happen is a baby calf would be born with that virus protein belonging to that genome and the calf would carry that virus and spread it to all the cows, so [farmers] became aware that [they] had all these ‘killer’ calves being born and the adult cows were getting sick with the infection that the calves were carrying… So, I think, this can be done with [humans]…
Mercola: …”basically [creating] superspreaders…”
Seneff: “Yes, and they killed these calves…when they found them…because they couldn’t afford to infect an entire herd…with this virus… So, a virus goes through this process; at first it’s new to the population and causes…disease and …eventually there’s, I think, something in a virus that’s needed , potentially, to get into [the body] system to help cope [with toxins].
–end transcript at min.37
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You Are What You EAT –and what eats you!
In light of the ‘healthy’ TMV-like content of baby guts, scrupulous consideration should be given to the current manipulation of tobamoviruses in plants and the discovery of vectoring these “plant” viruses by mosquitos!
Firstly, there’s the “flying syringe” funded in 2010:
· ‘Flying Syringe’ Mosquitoes Get Bill Gates Funding
http://www.bibliotecapleyades.net/ciencia/ciencia…
“The Bill and Melinda Gates Foundation awarded 100,000 dollars each on Wednesday to scientists in 22 countries including funding for a Japanese proposal to turn mosquitoes into “flying syringes” delivering vaccines. The charitable foundation created by the founder of software giant Microsoft said in a statement that the grants were designed to, “explore bold and largely unproven ways to improve global health.”
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—And then consider decades of experimentation on GMO food and crops with a newer link below to “foreign protein expression” obtained in tobacco: This citation appears to spin out of the same academic network as ’flying syringes’:
[Title] “Improvement of the transient expression system for production of recombinant protein in plants”… [text]”Transgenic plants are generally used to obtain recombinant proteins or identify the localization of proteins…The replication system of plant viruses results in high-level expression of foreign proteins within a few days..[and] can be easily amplified…[such as the] tobamovirus (TMV)-based deconstructed viral system [called] magnIcon [which] has been extensively engineered to achieve high levels of recombinant protein…[demonstrated by the vaccine] ZMapp for Ebolavirus infections…used during a recent outbreak… [Africa, 2014]” https://www.nature.com/articles/s41598-018-23024-y
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And then there’s evidence of tobacco use 12,000 years ago — do you think– as food?
Oldest Known Evidence of Tobacco Use in North America Found in Ice Age Hunting Camp
…. “the most interesting part of the discovery is that there is no direct evidence that people used tobacco past 3,000 years ago, but this research proved its use more than 12,000 years ago.”
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“You are what you eat: Sequence analysis reveals how plant microRNAs may regulate the human genome”
March 2019
Abstract
“Background: Nutrigenomic has revolutionized our understanding of nutrition. As plants make up a noticeable part of our diet, in the present study we chose microRNAs of edible plants and investigated if they can perfectly match human genes, indicating potential regulatory functionalities… Results: Four common plant miRNAs were identified to match perfectly with 22 human transcripts. The identified target genes were involved in a broad range of body functions, from muscle contraction to tumor suppression. We could also indicate some connections between these findings and folk herbology and botanical medicine…”
https://pubmed.ncbi.nlm.nih.gov/30708219/
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“Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi”
March 2017
“Background: Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression… Results: In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples… Conclusions: Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system.” https://pubmed.ncbi.nlm.nih.gov/28361700/
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The Long and Short of RNA
On the frontier of biological complexity is an ‘RNA world’ that prior to the 1980s, research scientists knew little about. They have since learned that most of the genetic material we carry is non-coding, meaning there are no specific proteins associated with it. This is our extraordinary and dynamic epigenome that directs cell functions, behavior, and identity. Professor John Mattick says in his presentation, The New World of RNA Biology, that “most of the genes in humans do not code for proteins”. He compares the known human “coding regions” with those of nematodes (hookworms, for example )as being numerically equivalent, “which means that [we have] more regulatory genes than genes –which is impossible [it was thought]…so, there’s another conversation about how eukaryotes solve this problem which is through microRNAs…and modularity.” Here’s his wonderful [one hour] ‘classroom’ video https://www.youtube.com/watch?v=WdltOXdwo4g
https://en.wikipedia.org/wiki/John_Mattick
RNA interference –RNAi
“RNAi encompasses an array of ancient and sophisticated cellular mechanisms that regulate a variety of biological functions. Argonaute proteins bind many naturally occurring small RNAs to defend against transposable elements, maintain chromosome structure and stability, and regulate developmental timing and differentiation. For example, microRNAs [miRNA] represent a natural form of developmentally-important siRNAs [small interfering RNA]… [O]ne microRNA [can] regulate hundreds of genes. Humans make more than 500 distinct microRNAs, and the inappropriate production of specific microRNAs has been linked to several diseases…” https://www.umassmed.edu/rti/biology/how-rnai-works/
RNAi, 10 minute video explanation by Maria Portela https://www.youtube.com/watch?v=C-pTiFkg1aU
A basic understanding of ‘RNA world’ is enough to follow the logic of what I’ll call “virus world,” as the lexicon of viruses has indeed absorbed the ‘transcript’ fragments from noncoding RNA (i.e. retrotransposons=endogenous viruses=’jumping genes’, etc.) and the endless variety of enzymes and proteins that are made for our adapting and evolving survival.
According to Dr. Mattick, the structural RNAs which build and shape our genes are those most familiar and studied by science: “There are studies going back to the 1960s showing that there are very stable chromatin-associated RNAs… RNA is the third component of chromatin and it’s nuclease resistant”, so it remains stable, resistant to enzymatic degradation—and those are qualities that make Tobacco Mosaic Virus so very interesting. TMV, in fact, looks like a chromatin stack. More than that, it has an observable relationship with the presence of human beings all over the world and deep into antiquity. TMV has more ‘mysteries’ than just its own genetics to reveal.
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Ebola, if you’re wondering, looks like TMV. I’ll have more to say (and show) about it in a future ‘Planting Viruses’. A particular TMV mystery is the “coat protein” homologue amino sequence that matches the human/mitochondria enzyme ‘TOMM40L’ found on chromosome 1. (ref. https://pubmed.ncbi.nlm.nih.gov/23573274/) The human/plant construct TOMM40L is known as a “translocase”:
“Translocase is a general term for a protein that assists in moving another molecule, usually across a cell membrane. These enzymes catalyze the movement of ions or molecules across membranes or their separation within membranes… It is also a historical term for the protein now called elongation factor G, due to its function in moving the transfer RNA (tRNA) and messenger RNA (mRNA) through the ribosome… Several of these [translocases] involve the hydrolysis of ATP and had been previously classified as ATPases (EC 3.6.3.-), although the hydrolytic reaction is not their primary function…
[Translocase Example #3 (of 3, at the bottom of the page): “Translocase of outer mitochondrial membrane 40 (TOMM40), a protein encoded by the TOMM40 gene, [is an enzyme] whose alleles differentially impact the risk for Alzheimer’s disease” https://en.wikipedia.org/wiki/Translocase Alzheimer ‘genes’ also encode on Chromosome 1.
And this is just one example, due probably to the extra attention of medical science on Alzheimers. In 2008 I read a special edition feature in the Los Angeles Times reporting that Americans then in early middle age could expect a 100% rate of Alzheimers.
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”Chromosome 1 is the designation for the largest human chromosome… It was the last completed chromosome, sequenced two decades after the beginning of the Human Genome Project… There are 890 known diseases related to this chromosome” –including porphyria and the single-point mutation disease of rapid premature aging called Hutchinson-Gilford Progeria. https://en.wikipedia.org/wiki/Chromosome_1
So far, however, there is only one claim of a completely sequenced chromosome, and it’s not chromosome 1. This past April it was widely published that chromosome 8 is the first –the additional entity sought by the COVID PCR tests.
Complete Chromosome 8 Sequence Reveals New Genes and Disease …
https://phys.org/news/2021-04-chromosome-sequence-reveals-genes-disease.html
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Look again at chromatin structure as it’s bound into a chromosome. Structure, of itself, is the manifestation of a chemical ‘story’.
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Building with RNA
“Architectural RNA in chromatin organization – “RNA plays a well-established architectural role in the formation of membraneless interchromatin nuclear bodies. However, a less well-known role of RNA is in organizing chromatin, whereby specific RNAs have been found to recruit chromatin modifier proteins… Studies… suggest that RNA plays a major direct architectural role in chromatin organization…” https://pubmed.ncbi.nlm.nih.gov/32897323/
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“Mammalian transcriptome analyses elucidated the presence of thousands of unannotated long noncoding RNAs (lncRNAs) with distinct transcriptional units. Molecular characterization and functional classification of these lncRNAs are important challenges in the next decade. A subset of these lncRNAs is the core of nuclear bodies, which are the sites of the biogenesis, maturation, storage, and sequestration of specific RNAs, proteins, and ribonucleoprotein complexes. Here, we define a class of lncRNAs termed architectural RNAs (arcRNAs) that function as the essential scaffold or platform of nuclear bodies. Presently, five lncRNAs from mammals, insects, and yeast are classified as arcRNAs. These arcRNAs are temporarily upregulated upon specific cellular stresses, in developmental stages, or in various disease conditions, and sequestrate specific regulatory proteins, thereby changing gene expression patterns.” https://pubmed.ncbi.nlm.nih.gov/26021608/
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“It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures…” https://link.springer.com/article/10.1007/s13258-020-00929-5
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Some months ago I posted this “shape matters” article which is mostly imagery of the mixed forms that occur in the “contagious virus” illnesses we’re familiar with –flu, for example– showing rods and spheres next to each other, touching each other, intermingled with the beads-on-a-string assembly that looks like chromatin subunits. I couldn’t say if any of these are “favorable or unfavorable chromatin structures” or even “viruses” as we’re told, but I go forward anyway on the premise of stress chemicals, unhindered by dogmatic contagion theories of disease. You’ll find an Ebolavirus comparison to Tobacco Mosaic Virus there too.
“Virus: Shape Matters” https://jenniferlake.wordpress.com/2020/12/09/virus-shape-matters/
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I’ll repost one ‘influenza’ image for you
And here’s another image not posted in Virus Shape Matters– this is a montage of H1N1
If there’s truth in advertising and these ‘influenza’ pictures are real specimens, what in the world –the RNA World—are we looking at? Image ‘D’ from H1N1, particularly, looks like a typical ‘mosaic’ or ‘mottle’ virus accumulation in plants.
Here’s an image below of infected soybean (glycine max) treated with anti-serum from cowpea mosaic virus –hopefully you can see the similarity in the viral matrix, the ‘stringbean’-like structures. With time and effort I can find a lot of pictures like these for side-by-side comparisons.
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The much-lauded ‘Lifespan’ researcher, David Sinclair writes that “what I’m about to suggest won’t actually come at the cost of human lives… Not even one. But it would require us to confront an idea that many people would find alarming: infecting ourselves with a virus that would quickly move into every cell in our body, turning us into genetically modified organisms. The virus wouldn’t kill; it would do the opposite. Vaccines against senescent cells, [calorie restriction] mimetics, and retrotransposon suppressors are possible pathways to prolonged vitality and work is under way already in labs and clinics around the world… [A] highly contagious disease…is…nothing more than a faster-acting version of aging.” –p158, Lifespan, David Sinclair, 2019
Immortality science, as we can easily deduce from ‘Lifespan,’ is currently dependent on vaccines. At no available technological point in this longevity treatment theory is there long life without injections. Sinclair sings the praises of vaccination: “the idea of giving a patient a little bit of a disease in order to prevent a lot of disease would have been seen as insane –even potentially homicidal—to many people until Jenner did it in 1796. We now know that vaccines are the single most effective medical intervention in human history in terms of saving and extending lifespans.” –p148, ibid. Edward Jenner’s vaccine subjects inconveniently died of diseases in their early twenties, but HEY! , they lived past their childhoods at a time when so many did not, and that’s life extension. Put that paradigm in your pocket. We now also know that cellular stress has benefits akin to direct immune challenge. “By engaging our bodies’ survival mechanisms in the absence of real adversity,” writes Sinclair, “will we push our lifespans far beyond what we can today?…The potential permutations are virtually endless.” –p144. So, we don’t need “real adversity”, like “a little bit of disease” anymore either, right?—just some engagement of our survival mechanisms. “There will come a time in which significantly prolonged vitality is indeed only a few pills away; there are too many promising leads, too many talented researchers, and too much momentum for it to be otherwise.” –p145, Lifespan.
“Life can potentially last forever, as long as it can preserve critical biological information and absorb energy from somewhere in the universe. This doesn’t mean we could be immortal tomorrow…” –p119. “I want to let you in on a secret. I have a window into the future. In 2028, a scientist will discover a new virus, called LINE-1. It will turn out that we are all infected with it. We get it from our parents. It will turn out that the LINE-1 virus is responsible for most other major diseases: diabetes, heart disease, cancer, dementia. It causes a slow, horrible chronic disorder, and all humans will succumb to it, even if they have a low-grade infection. Fortunately, the world pours billions into finding a cure. In 2033, a company will succeed in making a vaccine that prevents LINE-1 infections. New generations who are vaccinated at birth will live fifty years longer than their parents did—it will turn out that that’s our natural lifespan and we had no idea…. [and] it might be truer than you think.” –pp81-82.
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LINE-1 (the LINES and SINES that Stephanie Seneff and Joe Mercola mention) does exist. The LINEs are ‘Long’ and the SINEs are ‘short’ inserts into the very long strands of gene matter, where their function is ‘interference’ but their impulse is ‘repair’:
LINE-1 Retrotransposition Activity in Human Genomes –Jun 25, 2010 · Long Interspersed Element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome…” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013285/
This is no fantasy–“we are all infected with it. We get it from our parents…It causes a slow, horrible chronic disorder and all humans will succumb” because as David Sinclair points out, “when you disrupt the epigenome by forcing it to deal with DNA breaks, you introduce noise, leading to an erosion of the epigenetic landscape…[creating] bodies turned into chimeras of misguided, malfunctioning cells.” –p60. “Every time there’s a radical adjustment to the epigenome, say after DNA damage from the sun or an X-ray [or an ultrasound, or a vaccine injection], the marbles are jostled…. The marbles are moved… A cell’s identity changes. A skin cell starts behaving differently, turning on genes that were shut off in the womb and were meant to stay off. Now its 90 percent a skin cell and 10 percent other cell types, all mixed up, with properties [let’s say] of neurons and kidney cells. The cell becomes inept at the things skin cells must do… we say the cell has ex-differentiated…succumbing to epigenetic noise.”—pp59-60
He knows what we know: “the epigenome uses our genome to make the music of our lives.” –p37. “Up close, the epigenome is more complex and wonderful than anything we humans have invented.” –p36.
I accept that disclaimer, and always have. It is no virtue to identify ‘beauty’ in creation and act in variance –deviance– to it. The physicist Edward Teller, ‘father of the H-bomb,’ liked to relate a story of preparing and witnessing a Marshall Island test. He arrived a week before the scheduled explosion which was going to obliterate an entire tropical island and was so genuinely pleased with swimming in the clear lagoon and resting on the beach under the shade palms, as they all did, that he persisted in sharing his delight about the paradise lost. This is the mind of “interference,” defense, and weaponeers. Destruction is the price of knowledge and it is very, very interesting –worth the price because out there, up there, and somewhere in the future is the better world “we” will make.
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“Aging brings us to the precipice. Give any of us 100 years or so, and it brings us all there. In 1825, the British actuary Benjamin Gompertz, a learned member of the Royal Society, tried to explain this upward limit with a ‘Law of Human Mortality,’ essentially a mathematical description of aging. He wrote, “It is possible that death may be the consequence of two generally co-existing causes; the one, chance, without previous disposition to death or deterioration; the other, a deterioration, or an increased inability to withstand destruction.’ …Gompertz could accurately predict deaths due to aging: the number of people alive after 50 drops precipitously, but there is a tail at the end where some ‘lucky’ people remain alive beyond what you’d expect. His equations made his relatives, Sir Moses Montefiore and Nathan Mayer Rothschild, owners of the Alliance Insurance Company, a lot of money. What Gompertz could not have known, but would have appreciated, is that most organisms obey his law…” –p69– “Maintaining proteostasis, preventing deregulation of nutrient sensing, thwarting mitochondrial dysfunction, stopping senescence, rejuvenating stem cells, and decreasing inflammation might all be ways to delay the inevitable. Indeed, I work with students, postdocs, and companies around the globe that are developing solutions to each one of these hallmarks… Anything we can do…we should do…. Together we can build a single dam– at the source. Not just intervene when things go wrong. Not just slow things down. We can eliminate the symptoms of aging altogether.” –p84– “The discovery of the molecules I have described [in Lifespan] can be credited to a lot of serendipity. But imagine what the world will discover now that we’re actively and intentionally looking for molecules that engage our inbuilt defenses. Armies of chemists are now working to create and analyze natural and synthetic molecules that have the potential to be even better at suppressing epignomic noise and resetting our epigenetic landscape. There are hundreds of compounds… and hundreds of thousands more that are waiting to be researched. And it’s very possible that there is an as-yet-undiscovered chemical out there, hiding in a microorganism… And that’s just the natural chemicals, which are typically many times less effective than the synthetic drugs they inspire… It will take some time to sort out which of these molecules is best, when, and for whom. But we’re getting closer every day.” –p145.
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Armies of chemists, and chemists with armies
So, there’s DARPA. How ‘bout them? For years now, maybe decades, they’ve had this Tobacco Mosaic Virus vaccine. In 2012 we were told by DARPA that “this green goo might save your life”. Look up TMV in Wikipedia and you can sample the technologic wonder of what I’d call “nature’s carbon nanotube” and more. It’s particles can unwrap and rewrap into any ‘viral’ shape. This is really my purpose in posting Born Old: babies ‘born with TMV’. Before year 2000, nobody doing mainstream biomedicine research seems to have looked for it inside human beings, but what if it’s always been there and the “stress chemical” prospectors found it? What if it’s part of the ‘junk’ stacked on the tips of our chromosomes, masquerading as noncoding long repeats but really some remarkable human/plant relic that’s kept us alive by supporting creation of the other ‘stress chemicals’ ? What if TMV is the actual origin of the semi-fictitious “LINE-1 virus” that Sinclair speculates as infecting us all? Could TMV be the Alpha-Omega “We-Are-As-God—Rule-Of-The-Rod” answer to the immortal question?
I’m asking, I’m looking and I’ll keep you posted when there’s more to come. Army of one.
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Notes, links, and postscripts
Newborn immunity
“The clinical observation that the human newborn infant is uniquely susceptible to certain viral, fungal, protozoan, and bacterial infections has suggested that neonates may have impaired cell-mediated immune function…” https://pediatrics.aappublications.org/content/64/5/822
—cell-mediated immunity, called ‘Th1’ or ‘T1’ immunity, is individually acquired beginning at birth and develops through “training” by challenge. The secondary mechanism is called ‘Th2’ and involves the production of antibodies, normally transferred to infants from their mothers and provided by breastmilk until weaned. Vaccines disruptively over-induce the T2 antibody mechanisms at the cost of T1 cell-system development.
“In those first few months, the immune system — especially cell-mediated immunity — becomes more developed. This is very important in helping a child fight off viruses.”…(BUT, here’s the warning, they recommend that “ Keeping your infant up-to-date with vaccines is critical”) https://health.clevelandclinic.org/is-your-newborn-babys-immune-system-strong-enough/ –this is an ‘aligned’ military-medical-pharmaceutical industry entity.
“… studies of T cell-mediated immunity in human newborns and infants are scarce…” [2005] https://www.researchgate.net/publication/7784936_T_Cell-Mediated_Immune_Responses_in_Human_Newborns_Ready_to_Learn
…and it doesn’t stop them from experimenting with publicly administered vaccines.
2019 testimony statement by Dr. Meryl Nass: “Getting a vaccine approved for use during pregnancy is the newest Pharma gold rush. This despite evidence [16][17] (which CDC disputes) that flu vaccine is associated with a doubling of miscarriage rates, and evidence that anthrax vaccine increases the miscarriage rate.[18] Neither flu nor Tdap vaccines were tested and approved by FDA for use in pregnancy.” https://merylnassmd.com/my-testimony-on-legislation-to-remove_4/
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Progeria, the ‘single-point’ mutation disease, is not inherited.
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David A. Sinclair, author of Lifespan, began his rise in research studying Werner’s Disease, which causes rapid aging in early middle age –“average age at death is 46”. Werner’s is associated with chromosome 8.
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Chlamydia, a microorganism associated with chronic asthma, is an NAD-sucking parasite.
https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
Geoengineering and transbiology research has identified a chlamydia-like entity infecting blood cells https://www.aboutthesky.com/aboutthesky/transbiology
“The assessment is that Chlamydiae or Chlamydiae-like organisms should be considered as a leading candidate for investigation in the Morgellon’s pursuit as well as in the investigation of the aerosol operations. A more detailed analysis of the rationale behind that assessment will be provided in another paper, Agents of Infection as time and circumstance permit…” https://www.transitieweb.nl/mirror-carnicom-institute/and-now-our-children/index.html
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Jan 2021 – Abstract “The gut microbiome plays an important role in early life, protecting newborns from enteric pathogens, promoting immune system development and providing key functions to the infant host. Currently, there are limited data to broadly assess the status of the US healthy infant gut microbiome. To address this gap, we performed a multi-state metagenomic survey and found high levels of bacteria associated with enteric inflammation (e.g. Escherichia, Klebsiella), antibiotic resistance genes, and signatures of dysbiosis, independent of location, age, and diet. Bifidobacterium were less abundant than generally expected and the species identified, including B. breve, B. longum and B. bifidum, had limited genetic capacity to metabolize human milk oligosaccharides (HMOs), while B. infantis strains with a complete capacity for HMOs utilization were found to be exceptionally rare. Considering microbiome composition and functional capacity, this survey revealed a previously unappreciated dysbiosis that is widespread in the contemporary US infant gut microbiome.” https://www.nature.com/articles/s41598-020-80583-9
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[excerpt, 2015]
The Gut Microbiome’s Role in Asthma
The search for answers in the medical mystery around the recent increase in asthma prevalence, especially for children up to age four, has led researchers to consider changes in the gut and airway microbiome as a contributing environmental factor in the development of this treatable, but uncomfortable, condition.
Susan Lynch and Kei E. Fujimura of the University of California San Francisco present the latest research in mice exploring this relationship, especially how specific types of bacteria alter the presence of different immune cells. Though still an emerging body of work, they believe it is evidence that manipulation of the airway/gut microbiome at an early age could lead to new strategies to prevent or manage asthma.” https://www.sciencedaily.com/releases/2015/05/150513125126.htm
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Jennifer Lake's Blog 